Horizontal transfer of code fragments between protocells can explain the origins of the genetic code without vertical descent

Tom Froese, Jorge I. Campos, Kosuke Fujishima, Daisuke Kiga, Nathaniel Virgo

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    Theories of the origin of the genetic code typically appeal to natural selection and/or mutation of hereditable traits to explain its regularities and error robustness, yet the present translation system presupposes high-fidelity replication. Woese's solution to this bootstrapping problem was to assume that code optimization had played a key role in reducing the effect of errors caused by the early translation system. He further conjectured that initially evolution was dominated by horizontal exchange of cellular components among loosely organized protocells ("progenotes"), rather than by vertical transmission of genes. Here we simulated such communal evolution based on horizontal transfer of code fragments, possibly involving pairs of tRNAs and their cognate aminoacyl tRNA synthetases or a precursor tRNA ribozyme capable of catalysing its own aminoacylation, by using an iterated learning model. This is the first model to confirm Woese's conjecture that regularity, optimality, and (near) universality could have emerged via horizontal interactions alone.

    Original languageEnglish
    Article number3532
    JournalScientific Reports
    Volume8
    Issue number1
    DOIs
    Publication statusPublished - 2018 Dec 1

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    Artificial Cells
    Aminoacylation
    Genetic Code
    Amino Acyl-tRNA Synthetases
    Catalytic RNA
    Genetic Selection
    RNA Precursors
    Transfer RNA
    Learning
    Mutation
    Genes

    ASJC Scopus subject areas

    • General

    Cite this

    Horizontal transfer of code fragments between protocells can explain the origins of the genetic code without vertical descent. / Froese, Tom; Campos, Jorge I.; Fujishima, Kosuke; Kiga, Daisuke; Virgo, Nathaniel.

    In: Scientific Reports, Vol. 8, No. 1, 3532, 01.12.2018.

    Research output: Contribution to journalArticle

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