How polysulfone dialysis membranes containing polyvinylpyrrolidone achieve excellent biocompatibility?

Masayo Hayama, Ken Ichiro Yamamoto, Fukashi Kohori, Kiyotaka Sakai

    Research output: Contribution to journalArticle

    98 Citations (Scopus)

    Abstract

    Polysulfone (PS) dialysis membranes hydrophilized by blending polyvinylpyrrolidone (PVP) are well known to have excellent biocompatibility in clinical use. The objective of the present study is thus to clarify how PVP improves biocompatibility of PS membranes and furthermore to develop a patient-friendly PS dialysis membrane with higher biocompatibility. Biocompatibility based on both lactate dehydrogenase (LDH) activity and amount of protein adsorption was greatly different among four commercially available PS hollow-fiber dialysis membranes. PVP present on the inner surface of the hollow fiber was quantitatively determined by X-ray photoelectron spectroscopy (XPS), demonstrating the amount of PVP to be varying for each membrane. Structure parameters such as surface roughness, three-dimensional surface area and polymer particle diameter, indications of the physicochemical properties of the membranes, were measured on the observed inner surface images in both wet and dry conditions by atomic force microscopy (AFM) to account for dependence of biocompatibility on these structure parameters. The higher regularity polymer particle structure has in the wet condition, the lower wet/dry ratio surface roughness has and the larger wet/dry ratio polymer particle diameter has, that is, the more greatly the polymer particles swell by wetting, the higher biocompatibility is achieved by "cushion effect".

    Original languageEnglish
    Pages (from-to)41-49
    Number of pages9
    JournalJournal of Membrane Science
    Volume234
    Issue number1-2
    DOIs
    Publication statusPublished - 2004 May 1

    Fingerprint

    Dialysis membranes
    Povidone
    dialysis
    Polysulfones
    biocompatibility
    Biocompatibility
    Dialysis
    membranes
    Membranes
    Polymers
    polymers
    hollow
    surface roughness
    Surface roughness
    cushions
    Photoelectron Spectroscopy
    lactates
    dehydrogenases
    fibers
    Fibers

    Keywords

    • Atomic force microscopy
    • Biocompatibility
    • Dialysis membrane
    • Polysulfone
    • Polyvinylpyrrolidone

    ASJC Scopus subject areas

    • Filtration and Separation
    • Polymers and Plastics

    Cite this

    How polysulfone dialysis membranes containing polyvinylpyrrolidone achieve excellent biocompatibility? / Hayama, Masayo; Yamamoto, Ken Ichiro; Kohori, Fukashi; Sakai, Kiyotaka.

    In: Journal of Membrane Science, Vol. 234, No. 1-2, 01.05.2004, p. 41-49.

    Research output: Contribution to journalArticle

    Hayama, Masayo ; Yamamoto, Ken Ichiro ; Kohori, Fukashi ; Sakai, Kiyotaka. / How polysulfone dialysis membranes containing polyvinylpyrrolidone achieve excellent biocompatibility?. In: Journal of Membrane Science. 2004 ; Vol. 234, No. 1-2. pp. 41-49.
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