HOXB7 induces STAT3-mediated transformation and lung metastasis in immortalized mammary gland NMuMG cells

Kazushi Azuma; Mai Sakamoto; Shota Katayama; Atsuka Matsui; Kazuya Nakamichi; Naoki Goshima; Shinya Watanabe; Jun Nakayama; Kentaro Semba

doi:10.1111/gtc.13009

HOXB7 induces STAT3-mediated transformation and lung metastasis in immortalized mammary gland NMuMG cells

Kazushi Azuma, Mai Sakamoto, Shota Katayama, Atsuka Matsui, Kazuya Nakamichi, Naoki Goshima, Shinya Watanabe, Jun Nakayama^*, Kentaro Semba^*

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

The homeobox family genes are often dysregulated in various cancer types. Particularly HOXB7 amplification and overexpression correlate with poor prognosis in various cancer such as gastric, pancreatic, and lung cancers. Moreover, HOXB7 is known to contribute to cancer progression by promoting epithelial to mesenchymal transition, anticancer drug resistance, and angiogenesis. In this study, we show that HOXB7 is coamplified with ERBB2 in a subset of breast cancer patients and HOXB7 expression correlates with poor prognosis in HER2-positive breast cancer patients. This clinical observation is supported by the following results—HOXB7 overexpression in an immortalized murine mammary gland epithelial cell line NMuMG induces cellular transformation in vitro, tumorigenesis, and lung metastasis through the activation of JAK-STAT signaling.

Original language	English
Journal	Genes to Cells
DOIs	https://doi.org/10.1111/gtc.13009
Publication status	Accepted/In press - 2023

Keywords

breast cancer
ERBB2
HOXB7
metastasis
NMuMG
oncogene

ASJC Scopus subject areas

Genetics
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/gtc.13009

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title = "HOXB7 induces STAT3-mediated transformation and lung metastasis in immortalized mammary gland NMuMG cells",

abstract = "The homeobox family genes are often dysregulated in various cancer types. Particularly HOXB7 amplification and overexpression correlate with poor prognosis in various cancer such as gastric, pancreatic, and lung cancers. Moreover, HOXB7 is known to contribute to cancer progression by promoting epithelial to mesenchymal transition, anticancer drug resistance, and angiogenesis. In this study, we show that HOXB7 is coamplified with ERBB2 in a subset of breast cancer patients and HOXB7 expression correlates with poor prognosis in HER2-positive breast cancer patients. This clinical observation is supported by the following results—HOXB7 overexpression in an immortalized murine mammary gland epithelial cell line NMuMG induces cellular transformation in vitro, tumorigenesis, and lung metastasis through the activation of JAK-STAT signaling.",

keywords = "breast cancer, ERBB2, HOXB7, metastasis, NMuMG, oncogene",

author = "Kazushi Azuma and Mai Sakamoto and Shota Katayama and Atsuka Matsui and Kazuya Nakamichi and Naoki Goshima and Shinya Watanabe and Jun Nakayama and Kentaro Semba",

note = "Funding Information: This study was supported by JSPS KAKENHI (grant no. 23241064, Grant‐in‐Aid for Scientific Research (A) to K.S.; grant no. 18K16269: Grant‐in‐Aid for Early‐Career Scientist to J.N.; grant no. 20J01794, Grant in Aid for JSPS fellows to J.N.) and the Japan Biological Informatics Consortium (JBic). Publisher Copyright: {\textcopyright} 2023 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.",

year = "2023",

doi = "10.1111/gtc.13009",

language = "English",

journal = "Genes to Cells",

issn = "1356-9597",

publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - HOXB7 induces STAT3-mediated transformation and lung metastasis in immortalized mammary gland NMuMG cells

AU - Azuma, Kazushi

AU - Sakamoto, Mai

AU - Katayama, Shota

AU - Matsui, Atsuka

AU - Nakamichi, Kazuya

AU - Goshima, Naoki

AU - Watanabe, Shinya

AU - Nakayama, Jun

AU - Semba, Kentaro

N1 - Funding Information: This study was supported by JSPS KAKENHI (grant no. 23241064, Grant‐in‐Aid for Scientific Research (A) to K.S.; grant no. 18K16269: Grant‐in‐Aid for Early‐Career Scientist to J.N.; grant no. 20J01794, Grant in Aid for JSPS fellows to J.N.) and the Japan Biological Informatics Consortium (JBic). Publisher Copyright: © 2023 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

PY - 2023

Y1 - 2023

N2 - The homeobox family genes are often dysregulated in various cancer types. Particularly HOXB7 amplification and overexpression correlate with poor prognosis in various cancer such as gastric, pancreatic, and lung cancers. Moreover, HOXB7 is known to contribute to cancer progression by promoting epithelial to mesenchymal transition, anticancer drug resistance, and angiogenesis. In this study, we show that HOXB7 is coamplified with ERBB2 in a subset of breast cancer patients and HOXB7 expression correlates with poor prognosis in HER2-positive breast cancer patients. This clinical observation is supported by the following results—HOXB7 overexpression in an immortalized murine mammary gland epithelial cell line NMuMG induces cellular transformation in vitro, tumorigenesis, and lung metastasis through the activation of JAK-STAT signaling.

AB - The homeobox family genes are often dysregulated in various cancer types. Particularly HOXB7 amplification and overexpression correlate with poor prognosis in various cancer such as gastric, pancreatic, and lung cancers. Moreover, HOXB7 is known to contribute to cancer progression by promoting epithelial to mesenchymal transition, anticancer drug resistance, and angiogenesis. In this study, we show that HOXB7 is coamplified with ERBB2 in a subset of breast cancer patients and HOXB7 expression correlates with poor prognosis in HER2-positive breast cancer patients. This clinical observation is supported by the following results—HOXB7 overexpression in an immortalized murine mammary gland epithelial cell line NMuMG induces cellular transformation in vitro, tumorigenesis, and lung metastasis through the activation of JAK-STAT signaling.

KW - breast cancer

KW - ERBB2

KW - HOXB7

KW - metastasis

KW - NMuMG

KW - oncogene

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U2 - 10.1111/gtc.13009

DO - 10.1111/gtc.13009

M3 - Article

C2 - 36659836

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SN - 1356-9597

JO - Genes to Cells

JF - Genes to Cells

ER -

HOXB7 induces STAT3-mediated transformation and lung metastasis in immortalized mammary gland NMuMG cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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