Human c-fgr gene does not contain coding sequence for actin-like protein

Makoto Nishizawa, Kentaro Semba, Tadashi Yamamoto, Kumao Toyoshima

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2 Citations (Scopus)

Abstract

fgr is a member of the protein kinase oncogene family and was found to have the highest homology to yes gene among the members of the family. Using a v-yes probe, a molecular clone of human c-fgr locus was isolated from a genomic library. Nucleotide sequence determination revealed that the actin gene-like sequence found in v-fgr gene was absent at the corresponding position of the c-fgr gene. Thus, the v-fgr gene product is considered to be a tri-chimeric gene product consisting of viral gag gene and two distinct cellular genes, actin gene and the proto-fgr gene.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalJapanese Journal of Cancer Research GANN
Volume76
Issue number3
Publication statusPublished - 1985 Jan 1

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Keywords

  • Actin
  • Splicing junction
  • c-fgr

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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