Human cardiovascular and humoral responses to moderate muscle activation during dynamic exercise

Takeshi Nishiyasu, Kei Nagashima, Ethan R. Nadel, Gary W. Mack

Research output: Contribution to journalArticle

13 Citations (Scopus)


We examined the hypothesis that activation of the muscle metaboreflex during dynamic exercise would augment influences tending to cause a rise in arginine vasopressin, plasma renin activity, and catecholamines during dynamic exercise in humans. Ten healthy adults performed 30 min of supine cycle ergometer exercise at ~50% of peak oxygen consumption with or without moderate muscle metaboreflex activation by application of 35 mmHg lower body positive pressure (LBPP). Application of LBPP during the first 15 or last 15 min of exercise increased mean arterial blood pressure, plasma lactate concentration, and minute ventilation, indicating an activation of the muscle metaboreflex. These changes were rapidly reversed when LBPP was removed. During exercise at this intensity, LBPP augmented the release of arginine vasopressin and catecholamines but not of plasma renin activity. These results suggest that, although in humans hormonal responses are induced by moderate activation of the muscle metaboreflex during dynamic exercise, the thresholds for these responses may not be uniform among the various glands and hormones.

Original languageEnglish
Pages (from-to)300-307
Number of pages8
JournalJournal of Applied Physiology
Issue number1
Publication statusPublished - 2000 Jan
Externally publishedYes



  • Arginine vasopressin
  • Exercise
  • Lower body positive pressure
  • Mean arterial blood pressure
  • Muscle metaboreflex
  • Plasma renin activity

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this