Human immunodeficiency virus trans-activator of transcription peptide detection via ribonucleic acid aptamer on aminated diamond biosensor

A. Rahim Ruslinda, Xianfen Wang, Yoko Ishii, Yuichiro Ishiyama, Kyosuke Tanabe, Hiroshi Kawarada

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    The potential of ribonucleic acid (RNA) as both informational and ligand binding molecule have opened a scenario in the development of biosensors. An aminated diamond-based RNA aptasensor is presented for human immunodeficiency virus (HIV) trans-activator of transcription (Tat) peptide protein detection that not only gives a labeled or label-free detection method but also provides a reusable platform for a simple, sensitive, and selective detection of proteins. The immobilized procedure was based on the binding interaction between positively charged amine terminated diamond and the RNA aptamer probe molecules with the negatively charged surface carboxylic compound linker molecule such as terephthalic acid.

    Original languageEnglish
    Article number123702
    JournalApplied Physics Letters
    Volume99
    Issue number12
    DOIs
    Publication statusPublished - 2011 Sep 19

    Fingerprint

    ribonucleic acids
    human immunodeficiency virus
    bioinstrumentation
    peptides
    diamonds
    proteins
    molecules
    amines
    platforms
    ligands
    acids
    probes
    interactions

    ASJC Scopus subject areas

    • Physics and Astronomy (miscellaneous)

    Cite this

    Human immunodeficiency virus trans-activator of transcription peptide detection via ribonucleic acid aptamer on aminated diamond biosensor. / Rahim Ruslinda, A.; Wang, Xianfen; Ishii, Yoko; Ishiyama, Yuichiro; Tanabe, Kyosuke; Kawarada, Hiroshi.

    In: Applied Physics Letters, Vol. 99, No. 12, 123702, 19.09.2011.

    Research output: Contribution to journalArticle

    Rahim Ruslinda, A. ; Wang, Xianfen ; Ishii, Yoko ; Ishiyama, Yuichiro ; Tanabe, Kyosuke ; Kawarada, Hiroshi. / Human immunodeficiency virus trans-activator of transcription peptide detection via ribonucleic acid aptamer on aminated diamond biosensor. In: Applied Physics Letters. 2011 ; Vol. 99, No. 12.
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