Human immunodeficiency virus trans-activator of transcription peptide detection via ribonucleic acid aptamer on aminated diamond biosensor

A. Rahim Ruslinda, Xianfen Wang, Yoko Ishii, Yuichiro Ishiyama, Kyosuke Tanabe, Hiroshi Kawarada

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Abstract

The potential of ribonucleic acid (RNA) as both informational and ligand binding molecule have opened a scenario in the development of biosensors. An aminated diamond-based RNA aptasensor is presented for human immunodeficiency virus (HIV) trans-activator of transcription (Tat) peptide protein detection that not only gives a labeled or label-free detection method but also provides a reusable platform for a simple, sensitive, and selective detection of proteins. The immobilized procedure was based on the binding interaction between positively charged amine terminated diamond and the RNA aptamer probe molecules with the negatively charged surface carboxylic compound linker molecule such as terephthalic acid.

Original languageEnglish
Article number123702
JournalApplied Physics Letters
Volume99
Issue number12
DOIs
Publication statusPublished - 2011 Sep 19

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ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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