Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA

Shoko Hoshina; Kei Yura; Honami Teranishi; Noriko Kiyasu; Ayumi Tominaga; Haruka Kadoma; Ayaka Nakatsuka; Tomoko Kunichika; Chikashi Obuse; Shou Waga

doi:10.1074/jbc.M113.492504

Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA

Shoko Hoshina, Kei Yura, Honami Teranishi, Noriko Kiyasu, Ayumi Tominaga, Haruka Kadoma, Ayaka Nakatsuka, Tomoko Kunichika, Chikashi Obuse, Shou Waga

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

Background: ORC binds to replication origins, but human ORC does not exhibit apparent sequence-specificity. Results: G-quadruplex (G4)-preferable RNA or single-stranded DNA competes for DNA binding of ORC. Conclusion: HumanORCbinds preferentially toRNAand single-strandedDNAthat form G4, and the certain domain in ORC1 is involved in this binding. Significance: This ability may correlate with the G4-formable motif in human replication origins.

Original language	English
Pages (from-to)	30161-30171
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	42
DOIs	https://doi.org/10.1074/jbc.M113.492504
Publication status	Published - 2013 Oct 18
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1074/jbc.M113.492504

Fingerprint Dive into the research topics of 'Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA'. Together they form a unique fingerprint.

Cite this

Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA. / Hoshina, Shoko; Yura, Kei; Teranishi, Honami; Kiyasu, Noriko; Tominaga, Ayumi; Kadoma, Haruka; Nakatsuka, Ayaka; Kunichika, Tomoko; Obuse, Chikashi; Waga, Shou.

In: Journal of Biological Chemistry, Vol. 288, No. 42, 18.10.2013, p. 30161-30171.

Research output: Contribution to journal › Article › peer-review

@article{a6f480d66ee94ea6a13aa73abda12339,

title = "Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA",

abstract = "Background: ORC binds to replication origins, but human ORC does not exhibit apparent sequence-specificity. Results: G-quadruplex (G4)-preferable RNA or single-stranded DNA competes for DNA binding of ORC. Conclusion: HumanORCbinds preferentially toRNAand single-strandedDNAthat form G4, and the certain domain in ORC1 is involved in this binding. Significance: This ability may correlate with the G4-formable motif in human replication origins.",

author = "Shoko Hoshina and Kei Yura and Honami Teranishi and Noriko Kiyasu and Ayumi Tominaga and Haruka Kadoma and Ayaka Nakatsuka and Tomoko Kunichika and Chikashi Obuse and Shou Waga",

year = "2013",

month = oct,

day = "18",

doi = "10.1074/jbc.M113.492504",

language = "English",

volume = "288",

pages = "30161--30171",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "42",

}

TY - JOUR

T1 - Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA

AU - Hoshina, Shoko

AU - Yura, Kei

AU - Teranishi, Honami

AU - Kiyasu, Noriko

AU - Tominaga, Ayumi

AU - Kadoma, Haruka

AU - Nakatsuka, Ayaka

AU - Kunichika, Tomoko

AU - Obuse, Chikashi

AU - Waga, Shou

PY - 2013/10/18

Y1 - 2013/10/18

N2 - Background: ORC binds to replication origins, but human ORC does not exhibit apparent sequence-specificity. Results: G-quadruplex (G4)-preferable RNA or single-stranded DNA competes for DNA binding of ORC. Conclusion: HumanORCbinds preferentially toRNAand single-strandedDNAthat form G4, and the certain domain in ORC1 is involved in this binding. Significance: This ability may correlate with the G4-formable motif in human replication origins.

AB - Background: ORC binds to replication origins, but human ORC does not exhibit apparent sequence-specificity. Results: G-quadruplex (G4)-preferable RNA or single-stranded DNA competes for DNA binding of ORC. Conclusion: HumanORCbinds preferentially toRNAand single-strandedDNAthat form G4, and the certain domain in ORC1 is involved in this binding. Significance: This ability may correlate with the G4-formable motif in human replication origins.

UR - http://www.scopus.com/inward/record.url?scp=84886885078&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886885078&partnerID=8YFLogxK

U2 - 10.1074/jbc.M113.492504

DO - 10.1074/jbc.M113.492504

M3 - Article

C2 - 24003239

AN - SCOPUS:84886885078

VL - 288

SP - 30161

EP - 30171

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 42

ER -

Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this