Abstract
Background: ORC binds to replication origins, but human ORC does not exhibit apparent sequence-specificity. Results: G-quadruplex (G4)-preferable RNA or single-stranded DNA competes for DNA binding of ORC. Conclusion: HumanORCbinds preferentially toRNAand single-strandedDNAthat form G4, and the certain domain in ORC1 is involved in this binding. Significance: This ability may correlate with the G4-formable motif in human replication origins.
Original language | English |
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Pages (from-to) | 30161-30171 |
Number of pages | 11 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 42 |
DOIs | |
Publication status | Published - 2013 Oct 18 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology