Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA

Shoko Hoshina; Kei Yura; Honami Teranishi; Noriko Kiyasu; Ayumi Tominaga; Haruka Kadoma; Ayaka Nakatsuka; Tomoko Kunichika; Chikashi Obuse; Shou Waga

doi:10.1074/jbc.M113.492504

Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA

Shoko Hoshina, Kei Yura, Honami Teranishi, Noriko Kiyasu, Ayumi Tominaga, Haruka Kadoma, Ayaka Nakatsuka, Tomoko Kunichika, Chikashi Obuse, Shou Waga^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

Background: ORC binds to replication origins, but human ORC does not exhibit apparent sequence-specificity. Results: G-quadruplex (G4)-preferable RNA or single-stranded DNA competes for DNA binding of ORC. Conclusion: HumanORCbinds preferentially toRNAand single-strandedDNAthat form G4, and the certain domain in ORC1 is involved in this binding. Significance: This ability may correlate with the G4-formable motif in human replication origins.

Original language	English
Pages (from-to)	30161-30171
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	42
DOIs	https://doi.org/10.1074/jbc.M113.492504
Publication status	Published - 2013 Oct 18
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA. / Hoshina, Shoko; Yura, Kei; Teranishi, Honami; Kiyasu, Noriko; Tominaga, Ayumi; Kadoma, Haruka; Nakatsuka, Ayaka; Kunichika, Tomoko; Obuse, Chikashi; Waga, Shou.

In: Journal of Biological Chemistry, Vol. 288, No. 42, 18.10.2013, p. 30161-30171.

Research output: Contribution to journal › Article › peer-review

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title = "Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA",

abstract = "Background: ORC binds to replication origins, but human ORC does not exhibit apparent sequence-specificity. Results: G-quadruplex (G4)-preferable RNA or single-stranded DNA competes for DNA binding of ORC. Conclusion: HumanORCbinds preferentially toRNAand single-strandedDNAthat form G4, and the certain domain in ORC1 is involved in this binding. Significance: This ability may correlate with the G4-formable motif in human replication origins.",

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AU - Hoshina, Shoko

AU - Yura, Kei

AU - Teranishi, Honami

AU - Kiyasu, Noriko

AU - Tominaga, Ayumi

AU - Kadoma, Haruka

AU - Nakatsuka, Ayaka

AU - Kunichika, Tomoko

AU - Obuse, Chikashi

AU - Waga, Shou

PY - 2013/10/18

Y1 - 2013/10/18

N2 - Background: ORC binds to replication origins, but human ORC does not exhibit apparent sequence-specificity. Results: G-quadruplex (G4)-preferable RNA or single-stranded DNA competes for DNA binding of ORC. Conclusion: HumanORCbinds preferentially toRNAand single-strandedDNAthat form G4, and the certain domain in ORC1 is involved in this binding. Significance: This ability may correlate with the G4-formable motif in human replication origins.

AB - Background: ORC binds to replication origins, but human ORC does not exhibit apparent sequence-specificity. Results: G-quadruplex (G4)-preferable RNA or single-stranded DNA competes for DNA binding of ORC. Conclusion: HumanORCbinds preferentially toRNAand single-strandedDNAthat form G4, and the certain domain in ORC1 is involved in this binding. Significance: This ability may correlate with the G4-formable motif in human replication origins.

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Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA

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