Hydrodynamic characteristics of porcine aortic valves cross-linked with glutaraldehyde and polyepoxy compounds

Aiko Soda, Ryou Tanaka, Yuuto Saida, Kazuaki Takashima, Tomohiro Hirayama, Mitsuo Umezu, Yoshihisa Yamane

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    Porcine aortic valve (AoF) tissues cross-linked with glutaraldehyde and epoxy compounds were reported to have high anticalcification properties, but their hydrodynamic characteristics have not been evaluated. The aim of the present study was to investigate the hydrodynamic differences between porcine AoFs, cross-linked with concomitant use of an epoxy compound and glutaraldehyde, at different fixation periods. The valves were mounted on a pulsatile flow circulation mimicking a left heart. The left atrial and left ventricular pressures and mitral and aortic flows were measured at every 0.002 seconds, and the hydrodynamic factor of the valves mounted on the mitral position was estimated. Effective orifice area and the regurgitation volume, which are used as indicators of valve efficiency, failed to detect significant differences due to glutaraldehyde fixation time. In addition, the pressure gradient across the bioprosthetic valve and the variation of mitral flow also had no significant differences. The flow circuit model of the present study was mimicking of a left heart. The evaluation of the mitral valvular function with different glutaraldehyde fixation times was accomplished by relating the pressure with the flow, and by estimating the time lag between valve motion and transvalvular flow.

    Original languageEnglish
    Pages (from-to)13-18
    Number of pages6
    JournalASAIO Journal
    Volume55
    Issue number1
    DOIs
    Publication statusPublished - 2009 Jan

    Fingerprint

    Glutaral
    Hydrodynamics
    Aortic Valve
    Swine
    Epoxy Compounds
    Pulsatile flow
    Orifices
    Pressure gradient
    Pressure
    Pulsatile Flow
    Ventricular Pressure
    Mitral Valve
    Tissue
    Networks (circuits)

    ASJC Scopus subject areas

    • Biophysics
    • Biomaterials
    • Bioengineering
    • Biomedical Engineering
    • Medicine(all)

    Cite this

    Hydrodynamic characteristics of porcine aortic valves cross-linked with glutaraldehyde and polyepoxy compounds. / Soda, Aiko; Tanaka, Ryou; Saida, Yuuto; Takashima, Kazuaki; Hirayama, Tomohiro; Umezu, Mitsuo; Yamane, Yoshihisa.

    In: ASAIO Journal, Vol. 55, No. 1, 01.2009, p. 13-18.

    Research output: Contribution to journalArticle

    Soda, Aiko ; Tanaka, Ryou ; Saida, Yuuto ; Takashima, Kazuaki ; Hirayama, Tomohiro ; Umezu, Mitsuo ; Yamane, Yoshihisa. / Hydrodynamic characteristics of porcine aortic valves cross-linked with glutaraldehyde and polyepoxy compounds. In: ASAIO Journal. 2009 ; Vol. 55, No. 1. pp. 13-18.
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