Hydrolysis of oligoDNAs by lanthanide metal(III) chloride

Makoto Komiyama, Yoichi Matsumoto, Nobuhiro Hayashi, Kazunari Matsumura, Naoya Takeda, Kimitsuna Watanabe

Research output: Contribution to journalArticle

21 Citations (Scopus)


Selective scission of nucleic acids have been one of the most challenging topics and many artificial nucleases were discussed and reported. This paper aims to show that lanthanide metal ions efficiently cleave plasmid supercoiled DNA. Catalysis by these ions is applicable to the hydrolysis of both single-stranded and double-stranded linear DNAs. Results show that lanthanide metal ions especially Ce3+, hydrolyze DNA oligomers under mild conditions and findings strongly indicate high potentialities of the metal ions as the catalytic centers of hydrolytic artificial nucleases.

Original languageEnglish
Pages (from-to)1211-1214
Number of pages4
JournalPolymer Journal
Issue number11
Publication statusPublished - 1993
Externally publishedYes


ASJC Scopus subject areas

  • Materials Chemistry
  • Polymers and Plastics

Cite this

Komiyama, M., Matsumoto, Y., Hayashi, N., Matsumura, K., Takeda, N., & Watanabe, K. (1993). Hydrolysis of oligoDNAs by lanthanide metal(III) chloride. Polymer Journal, 25(11), 1211-1214.