Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis

Takayoshi Ubuka, Shogo Haraguchi, Yasuko Tobari, Misato Narihiro, Kei Ishikawa, Takanori Hayashi, Nobuhiro Harada, Kazuyoshi Tsutsui

    Research output: Contribution to journalArticle

    74 Citations (Scopus)

    Abstract

    Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that inhibits gonadotropin secretion and socio-sexual behaviours. Oestrogen (neuroestrogen) synthesized in the brain from androgen by aromatase regulates male socio-sexual behaviours. Here we show that GnIH directly activates aromatase and increases neuroestrogen synthesis in the preoptic area (POA) and inhibits socio-sexual behaviours of male quail. Aromatase activity and neuroestrogen concentration in the POA are low in the morning when the birds are active, but neuroestrogen synthesis gradually increases until the evening when the birds become inactive. Centrally administered GnIH in the morning increases neuroestrogen synthesis in the POA and decreases socio-sexual behaviours. Centrally administered 17β-oestradiol at higher doses also inhibits socio-sexual behaviours in the morning. These results suggest that GnIH inhibits male socio-sexual behaviours by increasing neuroestrogen synthesis beyond its optimum concentration for the expression of socio-sexual behaviours. This is the first demonstration of any hypothalamic neuropeptide that directly regulates neuroestrogen synthesis.

    Original languageEnglish
    Article number3061
    JournalNature Communications
    Volume5
    DOIs
    Publication statusPublished - 2014 Jan 16

    Fingerprint

    Gonadotropins
    Sexual Behavior
    Aromatase
    hormones
    Hormones
    synthesis
    Preoptic Area
    morning
    Birds
    Neuropeptides
    birds
    estrogens
    Androgens
    secretions
    evening
    Quail
    Estradiol
    Brain
    Estrogens
    Demonstrations

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • Chemistry(all)
    • Physics and Astronomy(all)

    Cite this

    Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis. / Ubuka, Takayoshi; Haraguchi, Shogo; Tobari, Yasuko; Narihiro, Misato; Ishikawa, Kei; Hayashi, Takanori; Harada, Nobuhiro; Tsutsui, Kazuyoshi.

    In: Nature Communications, Vol. 5, 3061, 16.01.2014.

    Research output: Contribution to journalArticle

    Ubuka, T, Haraguchi, S, Tobari, Y, Narihiro, M, Ishikawa, K, Hayashi, T, Harada, N & Tsutsui, K 2014, 'Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis', Nature Communications, vol. 5, 3061. https://doi.org/10.1038/ncomms4061
    Ubuka T, Haraguchi S, Tobari Y, Narihiro M, Ishikawa K, Hayashi T et al. Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis. Nature Communications. 2014 Jan 16;5. 3061. https://doi.org/10.1038/ncomms4061
    Ubuka, Takayoshi ; Haraguchi, Shogo ; Tobari, Yasuko ; Narihiro, Misato ; Ishikawa, Kei ; Hayashi, Takanori ; Harada, Nobuhiro ; Tsutsui, Kazuyoshi. / Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis. In: Nature Communications. 2014 ; Vol. 5.
    @article{f8d433242e7f471bb03d3f4680cad85c,
    title = "Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis",
    abstract = "Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that inhibits gonadotropin secretion and socio-sexual behaviours. Oestrogen (neuroestrogen) synthesized in the brain from androgen by aromatase regulates male socio-sexual behaviours. Here we show that GnIH directly activates aromatase and increases neuroestrogen synthesis in the preoptic area (POA) and inhibits socio-sexual behaviours of male quail. Aromatase activity and neuroestrogen concentration in the POA are low in the morning when the birds are active, but neuroestrogen synthesis gradually increases until the evening when the birds become inactive. Centrally administered GnIH in the morning increases neuroestrogen synthesis in the POA and decreases socio-sexual behaviours. Centrally administered 17β-oestradiol at higher doses also inhibits socio-sexual behaviours in the morning. These results suggest that GnIH inhibits male socio-sexual behaviours by increasing neuroestrogen synthesis beyond its optimum concentration for the expression of socio-sexual behaviours. This is the first demonstration of any hypothalamic neuropeptide that directly regulates neuroestrogen synthesis.",
    author = "Takayoshi Ubuka and Shogo Haraguchi and Yasuko Tobari and Misato Narihiro and Kei Ishikawa and Takanori Hayashi and Nobuhiro Harada and Kazuyoshi Tsutsui",
    year = "2014",
    month = "1",
    day = "16",
    doi = "10.1038/ncomms4061",
    language = "English",
    volume = "5",
    journal = "Nature Communications",
    issn = "2041-1723",
    publisher = "Nature Publishing Group",

    }

    TY - JOUR

    T1 - Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis

    AU - Ubuka, Takayoshi

    AU - Haraguchi, Shogo

    AU - Tobari, Yasuko

    AU - Narihiro, Misato

    AU - Ishikawa, Kei

    AU - Hayashi, Takanori

    AU - Harada, Nobuhiro

    AU - Tsutsui, Kazuyoshi

    PY - 2014/1/16

    Y1 - 2014/1/16

    N2 - Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that inhibits gonadotropin secretion and socio-sexual behaviours. Oestrogen (neuroestrogen) synthesized in the brain from androgen by aromatase regulates male socio-sexual behaviours. Here we show that GnIH directly activates aromatase and increases neuroestrogen synthesis in the preoptic area (POA) and inhibits socio-sexual behaviours of male quail. Aromatase activity and neuroestrogen concentration in the POA are low in the morning when the birds are active, but neuroestrogen synthesis gradually increases until the evening when the birds become inactive. Centrally administered GnIH in the morning increases neuroestrogen synthesis in the POA and decreases socio-sexual behaviours. Centrally administered 17β-oestradiol at higher doses also inhibits socio-sexual behaviours in the morning. These results suggest that GnIH inhibits male socio-sexual behaviours by increasing neuroestrogen synthesis beyond its optimum concentration for the expression of socio-sexual behaviours. This is the first demonstration of any hypothalamic neuropeptide that directly regulates neuroestrogen synthesis.

    AB - Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that inhibits gonadotropin secretion and socio-sexual behaviours. Oestrogen (neuroestrogen) synthesized in the brain from androgen by aromatase regulates male socio-sexual behaviours. Here we show that GnIH directly activates aromatase and increases neuroestrogen synthesis in the preoptic area (POA) and inhibits socio-sexual behaviours of male quail. Aromatase activity and neuroestrogen concentration in the POA are low in the morning when the birds are active, but neuroestrogen synthesis gradually increases until the evening when the birds become inactive. Centrally administered GnIH in the morning increases neuroestrogen synthesis in the POA and decreases socio-sexual behaviours. Centrally administered 17β-oestradiol at higher doses also inhibits socio-sexual behaviours in the morning. These results suggest that GnIH inhibits male socio-sexual behaviours by increasing neuroestrogen synthesis beyond its optimum concentration for the expression of socio-sexual behaviours. This is the first demonstration of any hypothalamic neuropeptide that directly regulates neuroestrogen synthesis.

    UR - http://www.scopus.com/inward/record.url?scp=84892703078&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84892703078&partnerID=8YFLogxK

    U2 - 10.1038/ncomms4061

    DO - 10.1038/ncomms4061

    M3 - Article

    VL - 5

    JO - Nature Communications

    JF - Nature Communications

    SN - 2041-1723

    M1 - 3061

    ER -