Hypothalamic LPXRF-amide peptides in vertebrates

Identification, localization and hypophysiotropic activity

Kazuyoshi Tsutsui, Kazuyoshi Ukena

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Probing undiscovered neuropeptides that play important roles in the regulation of pituitary function in vertebrates is essential for the progress of neuroendocrinology. Recently, we identified a novel hypothalamic neuropeptide with a C-terminal LPLRF-amide sequence in the quail brain. This avian neuropeptide was shown to be located in the hypothalamo-hypophysial system and to decrease gonadotropin release from cultured anterior pituitary. We, therefore, designated this novel neuropeptide as gonadotropin-inhibitory hormone (GnIH). We further identified novel hypothalamic neuropeptides closely related to GnIH in the brains of other vertebrates, such as mammals, amphibians, and fish. The identified neuropeptides possessed a LPXRF-amide (X = L or Q) motif at their C-termini. These LPXRF-amide peptides also were localized in the hypothalamus and other brainstem areas and regulated pituitary hormone release. Subsequently, cDNAs that encode LPXRF-amide peptides were characterized in vertebrate brains. In this review, we summarize the identification, localization, and hypophysiotropic activity of these newly identified hypothalamic LPXRF-amide peptides in vertebrates.

Original languageEnglish
Pages (from-to)1121-1129
Number of pages9
JournalPeptides
Volume27
Issue number5
DOIs
Publication statusPublished - 2006 May
Externally publishedYes

Fingerprint

Neuropeptides
Amides
Vertebrates
Peptides
Gonadotropins
Brain
Hypothalamo-Hypophyseal System
Neuroendocrinology
Hormones
Quail
Mammals
Pituitary Hormones
Amphibians
Fish
Hypothalamus
Brain Stem
Fishes
Complementary DNA

Keywords

  • Frog growth hormone-releasing peptide (fGRP)
  • Gonadotropin-inhibitory hormone (GnIH)
  • Hypophysiotropic activity
  • Hypothalamus
  • LPXRF-amide peptides
  • Pituitary
  • RF-amide peptides

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Hypothalamic LPXRF-amide peptides in vertebrates : Identification, localization and hypophysiotropic activity. / Tsutsui, Kazuyoshi; Ukena, Kazuyoshi.

In: Peptides, Vol. 27, No. 5, 05.2006, p. 1121-1129.

Research output: Contribution to journalArticle

@article{6435d715acce402abc5cfb8cf4c06aa6,
title = "Hypothalamic LPXRF-amide peptides in vertebrates: Identification, localization and hypophysiotropic activity",
abstract = "Probing undiscovered neuropeptides that play important roles in the regulation of pituitary function in vertebrates is essential for the progress of neuroendocrinology. Recently, we identified a novel hypothalamic neuropeptide with a C-terminal LPLRF-amide sequence in the quail brain. This avian neuropeptide was shown to be located in the hypothalamo-hypophysial system and to decrease gonadotropin release from cultured anterior pituitary. We, therefore, designated this novel neuropeptide as gonadotropin-inhibitory hormone (GnIH). We further identified novel hypothalamic neuropeptides closely related to GnIH in the brains of other vertebrates, such as mammals, amphibians, and fish. The identified neuropeptides possessed a LPXRF-amide (X = L or Q) motif at their C-termini. These LPXRF-amide peptides also were localized in the hypothalamus and other brainstem areas and regulated pituitary hormone release. Subsequently, cDNAs that encode LPXRF-amide peptides were characterized in vertebrate brains. In this review, we summarize the identification, localization, and hypophysiotropic activity of these newly identified hypothalamic LPXRF-amide peptides in vertebrates.",
keywords = "Frog growth hormone-releasing peptide (fGRP), Gonadotropin-inhibitory hormone (GnIH), Hypophysiotropic activity, Hypothalamus, LPXRF-amide peptides, Pituitary, RF-amide peptides",
author = "Kazuyoshi Tsutsui and Kazuyoshi Ukena",
year = "2006",
month = "5",
doi = "10.1016/j.peptides.2005.06.036",
language = "English",
volume = "27",
pages = "1121--1129",
journal = "Peptides",
issn = "0196-9781",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Hypothalamic LPXRF-amide peptides in vertebrates

T2 - Identification, localization and hypophysiotropic activity

AU - Tsutsui, Kazuyoshi

AU - Ukena, Kazuyoshi

PY - 2006/5

Y1 - 2006/5

N2 - Probing undiscovered neuropeptides that play important roles in the regulation of pituitary function in vertebrates is essential for the progress of neuroendocrinology. Recently, we identified a novel hypothalamic neuropeptide with a C-terminal LPLRF-amide sequence in the quail brain. This avian neuropeptide was shown to be located in the hypothalamo-hypophysial system and to decrease gonadotropin release from cultured anterior pituitary. We, therefore, designated this novel neuropeptide as gonadotropin-inhibitory hormone (GnIH). We further identified novel hypothalamic neuropeptides closely related to GnIH in the brains of other vertebrates, such as mammals, amphibians, and fish. The identified neuropeptides possessed a LPXRF-amide (X = L or Q) motif at their C-termini. These LPXRF-amide peptides also were localized in the hypothalamus and other brainstem areas and regulated pituitary hormone release. Subsequently, cDNAs that encode LPXRF-amide peptides were characterized in vertebrate brains. In this review, we summarize the identification, localization, and hypophysiotropic activity of these newly identified hypothalamic LPXRF-amide peptides in vertebrates.

AB - Probing undiscovered neuropeptides that play important roles in the regulation of pituitary function in vertebrates is essential for the progress of neuroendocrinology. Recently, we identified a novel hypothalamic neuropeptide with a C-terminal LPLRF-amide sequence in the quail brain. This avian neuropeptide was shown to be located in the hypothalamo-hypophysial system and to decrease gonadotropin release from cultured anterior pituitary. We, therefore, designated this novel neuropeptide as gonadotropin-inhibitory hormone (GnIH). We further identified novel hypothalamic neuropeptides closely related to GnIH in the brains of other vertebrates, such as mammals, amphibians, and fish. The identified neuropeptides possessed a LPXRF-amide (X = L or Q) motif at their C-termini. These LPXRF-amide peptides also were localized in the hypothalamus and other brainstem areas and regulated pituitary hormone release. Subsequently, cDNAs that encode LPXRF-amide peptides were characterized in vertebrate brains. In this review, we summarize the identification, localization, and hypophysiotropic activity of these newly identified hypothalamic LPXRF-amide peptides in vertebrates.

KW - Frog growth hormone-releasing peptide (fGRP)

KW - Gonadotropin-inhibitory hormone (GnIH)

KW - Hypophysiotropic activity

KW - Hypothalamus

KW - LPXRF-amide peptides

KW - Pituitary

KW - RF-amide peptides

UR - http://www.scopus.com/inward/record.url?scp=33646143547&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646143547&partnerID=8YFLogxK

U2 - 10.1016/j.peptides.2005.06.036

DO - 10.1016/j.peptides.2005.06.036

M3 - Article

VL - 27

SP - 1121

EP - 1129

JO - Peptides

JF - Peptides

SN - 0196-9781

IS - 5

ER -