Hypothalamic network for thermoregulatory shivering

Kazuyuki Kanosue, Y. H. Zhang, M. Yanase-Fujiwara, T. Hosono

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Warming one side of a rat's preoptic area and anterior hypothalamus (POAH) suppresses shivering on both sides of the body, and the present study evaluated the extent to which signals mediating this suppression cross the midline within and below the POAH. Hind paw shivering during unilateral POAH thermal stimulation was measured for rats in which the POAH had been midsagittally transected and for rats in which one side of the hypothalamus had been coronally transected just caudal to the POAH. In midsagittally transected rats, unilateral warming on either side of the POAH suppressed shivering equally on both sides of the body. In unilaterally transected rats, POAH warming on the transected side did not affect shivering, but warming the intact side suppressed shivering equally on both sides of the body. When a unilateral transection of only the lateral part of the hypothalamus included the medial forebrain bundle, the effect was the same as that of a unilateral transection of the whole hypothalamus. These results indicate that no information controlling shivering is exchanged between the left and right POAH and that efferent signals from the POAH, descending through the medial forebrain bundle, cross the midline somewhere below the hypothalamus to innervate both sides of the body equally.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume267
Issue number1 36-1
Publication statusPublished - 1994
Externally publishedYes

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Shivering
Anterior Hypothalamus
Preoptic Area
Medial Forebrain Bundle
Hypothalamus
Lateral Hypothalamic Area
Hot Temperature

Keywords

  • laterality
  • medial forebrain bundle
  • rat

ASJC Scopus subject areas

  • Physiology

Cite this

Hypothalamic network for thermoregulatory shivering. / Kanosue, Kazuyuki; Zhang, Y. H.; Yanase-Fujiwara, M.; Hosono, T.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 267, No. 1 36-1, 1994.

Research output: Contribution to journalArticle

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