Hypothalamic region facilitating shivering in rats

Mutsumi Tanaka, Mio Tonouchi, Takayoshi Hosono, Kei Nagashima, Motoko Yanase-Fujiwara, Kazuyuki Kanosue

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Although the posterior part of the hypothalamus has long been considered important for thermoregulatory shivering, it is unknown whether the neurons there or the passing fibers are implicated in the response. Exposure of urethane-anesthetized rats to cold (15-21°C) elicits shivering. An injection of muscimol (0.5mM), a GABAA receptor agonist, into the medial part of the hypothalamus, including the dorsomedial and posterior nuclei, suppressed the cold-induced shivering. This result suggests that neurons having an excitatory effect on shivering are in this region of the hypothalamus.

Original languageEnglish
Pages (from-to)625-629
Number of pages5
JournalJapanese Journal of Physiology
Volume51
Issue number5
DOIs
Publication statusPublished - 2001 Dec 1

Keywords

  • Dorsomedial hypothalamus
  • Posterior hypothalamus
  • Shivering

ASJC Scopus subject areas

  • Physiology

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