Identification and characterization of skin biomolecules for drug targeting and monitoring by vibrational spectroscopy

Natalja Skrebova Eikje, Katsuo Aizawa, Takayuki Sota, Yukihiro Ozaki, Seiji Arase

    Research output: Contribution to journalArticle

    Abstract

    The article discusses the application of vibrational spectroscopy techniques for in vivo identification and characterization of glucose biomolecules monitored in the skin of healthy, prediabetes and diabetes subjects; for molecular characterization of water and proteins in in vivo monitored patch tested inflamed skin of the patients with contact dermatitis; for description of nucleic acids and proteins at the molecular level with progression to malignancy in skin cancerous lesions. The results of the studies show new possibilities to assess activity levels of glucose metabolism in the skin tissue of healthy, prediabetes and diabetes subjects; activity and severity of inflammation; activity of the processes of carcinogenesis with regard to benign, premalignant and malignant transformation. Based on our findings, we suggest that vibrational spectroscopy might be a rapid screening tool with sufficient sensitivity and specificity to identify and characterize skin biomolecules in described diseases for drug targeting and monitoring by the pharmacological community.

    Original languageEnglish
    Pages (from-to)38-48
    Number of pages11
    JournalThe open medicinal chemistry journal
    Volume2
    DOIs
    Publication statusPublished - 2008 May 8

    Fingerprint

    Drug Monitoring
    Drug Delivery Systems
    Spectrum Analysis
    Skin
    Prediabetic State
    Glucose
    Contact Dermatitis
    Nucleic Acids
    Carcinogenesis
    Proteins
    Pharmacology
    Inflammation
    Sensitivity and Specificity
    Water
    Neoplasms

    Keywords

    • infrared spectroscopy
    • molecular characterization
    • molecular diagnosis
    • Raman spectroscopy
    • skin biomolecules
    • skin cancer
    • skin glucose.
    • skin inflammation
    • skin monitoring
    • Vibrational spectroscopy

    ASJC Scopus subject areas

    • Molecular Medicine
    • Pharmacology
    • Pharmaceutical Science
    • Drug Discovery

    Cite this

    Identification and characterization of skin biomolecules for drug targeting and monitoring by vibrational spectroscopy. / Eikje, Natalja Skrebova; Aizawa, Katsuo; Sota, Takayuki; Ozaki, Yukihiro; Arase, Seiji.

    In: The open medicinal chemistry journal, Vol. 2, 08.05.2008, p. 38-48.

    Research output: Contribution to journalArticle

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    abstract = "The article discusses the application of vibrational spectroscopy techniques for in vivo identification and characterization of glucose biomolecules monitored in the skin of healthy, prediabetes and diabetes subjects; for molecular characterization of water and proteins in in vivo monitored patch tested inflamed skin of the patients with contact dermatitis; for description of nucleic acids and proteins at the molecular level with progression to malignancy in skin cancerous lesions. The results of the studies show new possibilities to assess activity levels of glucose metabolism in the skin tissue of healthy, prediabetes and diabetes subjects; activity and severity of inflammation; activity of the processes of carcinogenesis with regard to benign, premalignant and malignant transformation. Based on our findings, we suggest that vibrational spectroscopy might be a rapid screening tool with sufficient sensitivity and specificity to identify and characterize skin biomolecules in described diseases for drug targeting and monitoring by the pharmacological community.",
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    AU - Arase, Seiji

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