Identification, biosynthesis, and function of 7α-hydroxypregnenolone, a new key neurosteroid controlling locomotor activity, in nonmammalian vertebrates

Kazuyoshi Tsutsui, Shogo Haraguchi, Kazuhiko Inoue, Hitomi Miyabara, Saori Suzuki, Yuki Ogura, Teppei Koyama, Masahiro Matsunaga, Hubert Vaudry

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    16 Citations (Scopus)

    Abstract

    It is now clearly established that steroids can be synthesized de novo by the brain and the peripheral nervous systems. Such steroids are called neurosteroids, and de novo neurosteroidogenesis from cholesterol is a conserved property of vertebrate brains. Our studies over the past decade have demonstrated that the brain expresses several kinds of steroidogenic enzymes and produces a variety of neurosteroids in submammalian species. However, the biosynthetic pathway of neurosteroids in nonmammalian vertebrates as well as in mammals may be still incompletely mapped out. We recently found that the brain of newts and quail actively produces 7α-hydroxypregnenolone, a novel bioactive neurosteroid, from pregnenolone. Interestingly, 7α- hydroxypregnenolone stimulates locomotor activity by means of the dopaminergic system. Subsequently, we demonstrated that melatonin regulates synthesis of 7α-hydroxypregnenolone, a key factor for induction of locomotor activity, thus inducing diurnal locomotor changes.

    Original languageEnglish
    Title of host publicationAnnals of the New York Academy of Sciences
    Pages308-315
    Number of pages8
    Volume1163
    DOIs
    Publication statusPublished - 2009 Apr

    Publication series

    NameAnnals of the New York Academy of Sciences
    Volume1163
    ISSN (Print)00778923
    ISSN (Electronic)17496632

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    Keywords

    • 7α-hydroxypregnenolone
    • Diurnal changes
    • Dopamine
    • Locomotor activity
    • Melatonin
    • Neurosteroids

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Tsutsui, K., Haraguchi, S., Inoue, K., Miyabara, H., Suzuki, S., Ogura, Y., Koyama, T., Matsunaga, M., & Vaudry, H. (2009). Identification, biosynthesis, and function of 7α-hydroxypregnenolone, a new key neurosteroid controlling locomotor activity, in nonmammalian vertebrates. In Annals of the New York Academy of Sciences (Vol. 1163, pp. 308-315). (Annals of the New York Academy of Sciences; Vol. 1163). https://doi.org/10.1111/j.1749-6632.2009.04426.x