Identification, localization and function of a novel neuropeptide, 26RFa, and its cognate receptor, GPR103, in the avian hypothalamus

Kazuyoshi Ukena, Tetsuya Tachibana, Yasuko Tobari, JérÔme Leprince, Hubert Vaudry, Kazuyoshi Tsutsui

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    Several neuropeptides possessing the RFamide motif at their C-termini (designated RFamide peptides) have been characterized in the hypothalamus of a variety of vertebrates. Since the discovery of the 26-amino acid RFamide peptide (termed 26RFa) from the frog brain, 26RFa has been shown to exert orexigenic activity in mammals and to be a ligand of the previously identified orphan G protein-coupled receptor GPR103. Recently, we have identified 26RFa in the avian brain by molecular cloning of the cDNA encoding the 26RFa precursor and mass spectrometry analysis of the mature peptide. 26RFa-producing neurons are exclusively located in the hypothalamus whereas GPR103 is widely distributed in the avian brain. Furthermore, avian 26RFa stimulates feeding behavior in broiler chicks. This review summarizes the advances in the identification, localization, and functions of 26RFa and its cognate receptor GPR103 in vertebrates and highlights recent progress made in birds.

    Original languageEnglish
    Pages (from-to)42-46
    Number of pages5
    JournalGeneral and Comparative Endocrinology
    Volume190
    DOIs
    Publication statusPublished - 2012 Jun 5

    Keywords

    • 26RFa
    • Food intake
    • G protein-coupled receptor
    • Hypothalamus
    • Neuropeptide

    ASJC Scopus subject areas

    • Endocrinology

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