Identification of large ancient duplications associated with human gene deserts

Takehiko Itoh; Atsushi Toyoda; Todd D. Taylor; Yoshiyuki Sakaki; Masahira Hattori

doi:10.1038/ng1648

Identification of large ancient duplications associated with human gene deserts

Takehiko Itoh, Atsushi Toyoda, Todd D. Taylor, Yoshiyuki Sakaki, Masahira Hattori

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4 Citations (Scopus)

Abstract

We identified 15 regions of >1 Mb in the human genome composed of large ancient local duplications corresponding to gene deserts. We detected these intrachromosomal duplications in mouse and dog but not in chicken; they present as patches of similarity as low as 60%. These findings suggest that some human gene deserts originated from duplications of segments lacking genes in a mammalian common ancestor.

Original language	English
Pages (from-to)	1041-1043
Number of pages	3
Journal	Nature Genetics
Volume	37
Issue number	10
DOIs	https://doi.org/10.1038/ng1648
Publication status	Published - 2005 Oct
Externally published	Yes

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ASJC Scopus subject areas

Genetics(clinical)
Genetics

Cite this

Itoh, T., Toyoda, A., Taylor, T. D., Sakaki, Y., & Hattori, M. (2005). Identification of large ancient duplications associated with human gene deserts. Nature Genetics, 37(10), 1041-1043. https://doi.org/10.1038/ng1648

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10.1038/ng1648