Identification of large ancient duplications associated with human gene deserts

Takehiko Itoh, Atsushi Toyoda, Todd D. Taylor, Yoshiyuki Sakaki, Masahira Hattori

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We identified 15 regions of >1 Mb in the human genome composed of large ancient local duplications corresponding to gene deserts. We detected these intrachromosomal duplications in mouse and dog but not in chicken; they present as patches of similarity as low as 60%. These findings suggest that some human gene deserts originated from duplications of segments lacking genes in a mammalian common ancestor.

Original languageEnglish
Pages (from-to)1041-1043
Number of pages3
JournalNature Genetics
Volume37
Issue number10
DOIs
Publication statusPublished - 2005 Oct
Externally publishedYes

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Genes
Human Genome
Chickens
Dogs

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Identification of large ancient duplications associated with human gene deserts. / Itoh, Takehiko; Toyoda, Atsushi; Taylor, Todd D.; Sakaki, Yoshiyuki; Hattori, Masahira.

In: Nature Genetics, Vol. 37, No. 10, 10.2005, p. 1041-1043.

Research output: Contribution to journalArticle

Itoh, Takehiko ; Toyoda, Atsushi ; Taylor, Todd D. ; Sakaki, Yoshiyuki ; Hattori, Masahira. / Identification of large ancient duplications associated with human gene deserts. In: Nature Genetics. 2005 ; Vol. 37, No. 10. pp. 1041-1043.
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