Identification of large ancient duplications associated with human gene deserts

Takehiko Itoh*, Atsushi Toyoda, Todd D. Taylor, Yoshiyuki Sakaki, Masahira Hattori

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


We identified 15 regions of >1 Mb in the human genome composed of large ancient local duplications corresponding to gene deserts. We detected these intrachromosomal duplications in mouse and dog but not in chicken; they present as patches of similarity as low as 60%. These findings suggest that some human gene deserts originated from duplications of segments lacking genes in a mammalian common ancestor.

Original languageEnglish
Pages (from-to)1041-1043
Number of pages3
JournalNature Genetics
Issue number10
Publication statusPublished - 2005 Oct
Externally publishedYes

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics


Dive into the research topics of 'Identification of large ancient duplications associated with human gene deserts'. Together they form a unique fingerprint.

Cite this