Abstract
We identified 15 regions of >1 Mb in the human genome composed of large ancient local duplications corresponding to gene deserts. We detected these intrachromosomal duplications in mouse and dog but not in chicken; they present as patches of similarity as low as 60%. These findings suggest that some human gene deserts originated from duplications of segments lacking genes in a mammalian common ancestor.
| Original language | English |
|---|---|
| Pages (from-to) | 1041-1043 |
| Number of pages | 3 |
| Journal | Nature Genetics |
| Volume | 37 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2005 Oct |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics(clinical)
- Genetics
Cite this
Identification of large ancient duplications associated with human gene deserts. / Itoh, Takehiko; Toyoda, Atsushi; Taylor, Todd D.; Sakaki, Yoshiyuki; Hattori, Masahira.
In: Nature Genetics, Vol. 37, No. 10, 10.2005, p. 1041-1043.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Identification of large ancient duplications associated with human gene deserts
AU - Itoh, Takehiko
AU - Toyoda, Atsushi
AU - Taylor, Todd D.
AU - Sakaki, Yoshiyuki
AU - Hattori, Masahira
PY - 2005/10
Y1 - 2005/10
N2 - We identified 15 regions of >1 Mb in the human genome composed of large ancient local duplications corresponding to gene deserts. We detected these intrachromosomal duplications in mouse and dog but not in chicken; they present as patches of similarity as low as 60%. These findings suggest that some human gene deserts originated from duplications of segments lacking genes in a mammalian common ancestor.
AB - We identified 15 regions of >1 Mb in the human genome composed of large ancient local duplications corresponding to gene deserts. We detected these intrachromosomal duplications in mouse and dog but not in chicken; they present as patches of similarity as low as 60%. These findings suggest that some human gene deserts originated from duplications of segments lacking genes in a mammalian common ancestor.
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U2 - 10.1038/ng1648
DO - 10.1038/ng1648
M3 - Article
VL - 37
SP - 1041
EP - 1043
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 10
ER -