Identification of large ancient duplications associated with human gene deserts

Takehiko Itoh, Atsushi Toyoda, Todd D. Taylor, Yoshiyuki Sakaki, Masahira Hattori

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We identified 15 regions of >1 Mb in the human genome composed of large ancient local duplications corresponding to gene deserts. We detected these intrachromosomal duplications in mouse and dog but not in chicken; they present as patches of similarity as low as 60%. These findings suggest that some human gene deserts originated from duplications of segments lacking genes in a mammalian common ancestor.

Original languageEnglish
Pages (from-to)1041-1043
Number of pages3
JournalNature Genetics
Volume37
Issue number10
DOIs
Publication statusPublished - 2005 Oct
Externally publishedYes

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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  • Cite this

    Itoh, T., Toyoda, A., Taylor, T. D., Sakaki, Y., & Hattori, M. (2005). Identification of large ancient duplications associated with human gene deserts. Nature Genetics, 37(10), 1041-1043. https://doi.org/10.1038/ng1648