Abstract
We identified 15 regions of >1 Mb in the human genome composed of large ancient local duplications corresponding to gene deserts. We detected these intrachromosomal duplications in mouse and dog but not in chicken; they present as patches of similarity as low as 60%. These findings suggest that some human gene deserts originated from duplications of segments lacking genes in a mammalian common ancestor.
Original language | English |
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Pages (from-to) | 1041-1043 |
Number of pages | 3 |
Journal | Nature Genetics |
Volume | 37 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2005 Oct |
Externally published | Yes |
ASJC Scopus subject areas
- Genetics(clinical)
- Genetics