Identification of renieramycin a as an antileishmanial substance in a marine sponge neopetrosia sp.

Yoichi Nakao, Takeru Shiroiwa, Shuhei Murayama, Shigeki Matsunaga, Yasuyuki Goto, Yoshitsugu Matsumoto, Nobuhiro Fusetani*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which was identified as renieramycin A by spectroscopic analysis. It inhibited La/egfp with an IC50 value of 0.2 µg/mL.

Original languageEnglish
Pages (from-to)55-62
Number of pages8
JournalMarine Drugs
Volume2
Issue number2
DOIs
Publication statusPublished - 2004 Jun
Externally publishedYes

Keywords

  • Leishmaniasis
  • Marine sponge
  • Renieramycin A

ASJC Scopus subject areas

  • Drug Discovery

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