Identification of the brain networks that contribute to the interaction between physical function and working memory: An fMRI investigation with over 1,000 healthy adults

Toru Ishihara, Atsushi Miyazaki, Hiroki Tanaka, Tetsuya Matsuda*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

There is a growing consensus regarding the positive relationship between physical function and working memory; however, explanations of task-evoked functional activity regarding this relationship and its differences in physical function domains remain controversial. This study illustrates the cross-sectional relationships between cardiorespiratory fitness, gait speed, hand dexterity, and muscular strength with working memory task (N-back task) performance and the mediating effects of task-evoked functional activity in 1033 adults aged between 22 and 37 years. The results showed that cardiorespiratory fitness and hand dexterity were independently associated with N-back task performance to a greater extent and in contrast to gait speed and muscular strength. These relationships were mediated by task-evoked functional activity in a part of the frontoparietal network (FPN) and default mode network (DMN). Superior cardiorespiratory fitness could contribute to working memory performance by enhancing the compensational role of FPN-related broader region activation. Hand dexterity was associated with moderation of the interaction in terms of task-evoked activation between the FPN and DMN, which in turn, improved N-back task performance. Based on these findings, we conclude that cardiorespiratory fitness and hand dexterity have common and unique mechanisms enhancing working memory.

Original languageEnglish
Article number117152
JournalNeuroImage
Volume221
DOIs
Publication statusPublished - 2020 Nov 1
Externally publishedYes

Keywords

  • Cardiorespiratory fitness
  • Cognitive control
  • Default mode network
  • Dorsolateral prefrontal cortex
  • Frontoparietal network
  • Hand dexterity

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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