Identification of transposable elements contributing to tissue-specific expression of long non-coding RNAs

Takafumi Chishima, Junichi Iwakiri, Michiaki Hamada

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    It has been recently suggested that transposable elements (TEs) are re-used as functional elements of long non-coding RNAs (lncRNAs). This is supported by some examples such as the human endogenous retrovirus subfamily H (HERVH) elements contained within lncRNAs and expressed specifically in human embryonic stem cells (hESCs), as required to maintain hESC identity. There are at least two unanswered questions about all lncRNAs. How many TEs are re-used within lncRNAs? Are there any other TEs that affect tissue specificity of lncRNA expression? To answer these questions, we comprehensively identify TEs that are significantly related to tissue-specific expression levels of lncRNAs. We downloaded lncRNA expression data corresponding to normal human tissue from the Expression Atlas and transformed the data into tissue specificity estimates. Then, Fisher’s exact tests were performed to verify whether the presence or absence of TE-derived sequences influences the tissue specificity of lncRNA expression. Many TE–tissue pairs associated with tissue-specific expression of lncRNAs were detected, indicating that multiple TE families can be re-used as functional domains or regulatory sequences of lncRNAs. In particular, we found that the antisense promoter region of L1PA2, a LINE-1 subfamily, appears to act as a promoter for lncRNAs with placenta-specific expression.

    Original languageEnglish
    Article number23
    JournalGenes
    Volume9
    Issue number1
    DOIs
    Publication statusPublished - 2018 Jan 1

    Fingerprint

    Long Noncoding RNA
    DNA Transposable Elements
    Organ Specificity
    Endogenous Retroviruses
    Atlases
    Genetic Promoter Regions
    Placenta

    Keywords

    • Long non-coding RNA
    • Tissue-specific expression
    • Transposable element

    ASJC Scopus subject areas

    • Genetics
    • Genetics(clinical)

    Cite this

    Identification of transposable elements contributing to tissue-specific expression of long non-coding RNAs. / Chishima, Takafumi; Iwakiri, Junichi; Hamada, Michiaki.

    In: Genes, Vol. 9, No. 1, 23, 01.01.2018.

    Research output: Contribution to journalArticle

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