Identification of two novel primate-specific genes in DSCR

Kunihiko Takamatsu, Kohei Maekawa, Takushi Togashi, Dong Kug Choi, Yutaka Suzuki, Todd D. Taylor, Atsushi Toyoda, Sumio Sugano, Asao Fujiyama, Masahira Hattori, Yoshiyuki Sakaki, Tadayuki Takeda

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We recently helped to complete the sequence of human chromosome 21 at a very high level of accuracy. Using this sequence we identified two novel genes, designated DSCR9 and DSCR10, in the so-called Down Syndrome Critical Region (DSCR) by computational gene prediction and subsequent cDNA cloning. Both DSCR9 and DSCR10 are expressed preferentially in testis and encode functionally unknown proteins with 149 and 87 amino acid residues, respectively. Zoo blot analysis suggested that both genes are exclusive to primate genomes such as chimpanzee, gorilla, orangutan, crab-eating monkey and African green monkey but are not present in other non-primate mammals including mouse, dog, cat, and chicken. Comparative genomic sequence analysis of DSCR9 and DSCR10 with the corresponding mouse syntenic region confirmed the lack of these genes in the mouse. These results strongly suggest that DSCR9 and DSCR10 have emerged as a new class of gene in the primate lineage during evolution.

Original languageEnglish
Pages (from-to)89-97
Number of pages9
JournalDNA Research
Volume9
Issue number3
DOIs
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Primates
Genes
Pongo
Gorilla gorilla
Cercopithecus aethiops
Chromosomes, Human, Pair 21
Macaca fascicularis
Pan troglodytes
Human Chromosomes
Sequence Analysis
Testis
Organism Cloning
Mammals
Chickens
Cats
Complementary DNA
Down Syndrome Critical Region
Genome
Dogs
Amino Acids

Keywords

  • CDNA cloning
  • Down Syndrome Critical Region
  • Primate-specific genes

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology

Cite this

Takamatsu, K., Maekawa, K., Togashi, T., Choi, D. K., Suzuki, Y., Taylor, T. D., ... Takeda, T. (2002). Identification of two novel primate-specific genes in DSCR. DNA Research, 9(3), 89-97. https://doi.org/10.1093/dnares/9.3.89

Identification of two novel primate-specific genes in DSCR. / Takamatsu, Kunihiko; Maekawa, Kohei; Togashi, Takushi; Choi, Dong Kug; Suzuki, Yutaka; Taylor, Todd D.; Toyoda, Atsushi; Sugano, Sumio; Fujiyama, Asao; Hattori, Masahira; Sakaki, Yoshiyuki; Takeda, Tadayuki.

In: DNA Research, Vol. 9, No. 3, 2002, p. 89-97.

Research output: Contribution to journalArticle

Takamatsu, K, Maekawa, K, Togashi, T, Choi, DK, Suzuki, Y, Taylor, TD, Toyoda, A, Sugano, S, Fujiyama, A, Hattori, M, Sakaki, Y & Takeda, T 2002, 'Identification of two novel primate-specific genes in DSCR', DNA Research, vol. 9, no. 3, pp. 89-97. https://doi.org/10.1093/dnares/9.3.89
Takamatsu K, Maekawa K, Togashi T, Choi DK, Suzuki Y, Taylor TD et al. Identification of two novel primate-specific genes in DSCR. DNA Research. 2002;9(3):89-97. https://doi.org/10.1093/dnares/9.3.89
Takamatsu, Kunihiko ; Maekawa, Kohei ; Togashi, Takushi ; Choi, Dong Kug ; Suzuki, Yutaka ; Taylor, Todd D. ; Toyoda, Atsushi ; Sugano, Sumio ; Fujiyama, Asao ; Hattori, Masahira ; Sakaki, Yoshiyuki ; Takeda, Tadayuki. / Identification of two novel primate-specific genes in DSCR. In: DNA Research. 2002 ; Vol. 9, No. 3. pp. 89-97.
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