IL-17, neutrophil activation and muscle damage following endurance exercise.

Kaoru Sugama, Katsuhiko Suzuki, Kayo Yoshitani, Koso Shiraishi, Takashi Kometani

Research output: Contribution to journalArticle

Abstract

The T-cell subset Th17 is induced partly by interleukin (IL)-6 and activated by IL-23, and produces a proinflammatory cytokine IL-17. Since IL-6 increases dramatically following long-lasting endurance exercise, this response may also stimulate the induction of IL-17 and IL-23 after exercise. The aim of this study was to clarify the dynamics of IL-17 in association with endurance exercise-induced muscle damage and inflammatory responses. Fourteen male triathletes participated in a duathlon race consisting of 5 km of running, 40 km of cycling and 5 km of running. Venous blood and urine samples were collected before, immediately after 1.5 h and 3 h after the race. Plasma and urine were analyzed using enzyme-linked immunosorbent assays (ELISA). Haematological and biochemical variables such as neutrophil activation marker (myeloperoxidase: MPO), muscle damage marker (myoglobin: Mb) and soluble receptor activator of nuclear factor (NF)-KB ligand (sRANKL) were also determined to estimate the biological and pathological significance. Plasma concentrations oflL-6 (+26.0x), MPO (+3.2x) and Mb (+4.9x) increased significantly immediately after the race and IL-17 and IL-23 tended to increase. Furthermore, plasma concentrations of IL-12p40 and sRANKL increased significantly after the race. The measured parameters related to Thl 7 cytokines in the urinary output were closely correlated with each other and muscle damage marker. These findings suggest that IL-17 induced by IL-6 and activated by IL-23 or other IL-17 producing-cells and IL-23 might promote neutrophil activation and muscle damage following prolonged endurance exercise.

Original languageEnglish
Pages (from-to)116-127
Number of pages12
JournalExercise Immunology Review
Volume18
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Neutrophil Activation
Interleukin-17
Interleukin-23
Exercise
Muscles
Interleukin-6
Running
Urine
Cytokines
Myoglobin
Interleukins
T-Lymphocyte Subsets
Cytoplasmic and Nuclear Receptors
Peroxidase
Enzyme-Linked Immunosorbent Assay
Ligands

ASJC Scopus subject areas

  • Immunology

Cite this

Sugama, K., Suzuki, K., Yoshitani, K., Shiraishi, K., & Kometani, T. (2012). IL-17, neutrophil activation and muscle damage following endurance exercise. Exercise Immunology Review, 18, 116-127.

IL-17, neutrophil activation and muscle damage following endurance exercise. / Sugama, Kaoru; Suzuki, Katsuhiko; Yoshitani, Kayo; Shiraishi, Koso; Kometani, Takashi.

In: Exercise Immunology Review, Vol. 18, 2012, p. 116-127.

Research output: Contribution to journalArticle

Sugama, K, Suzuki, K, Yoshitani, K, Shiraishi, K & Kometani, T 2012, 'IL-17, neutrophil activation and muscle damage following endurance exercise.', Exercise Immunology Review, vol. 18, pp. 116-127.
Sugama, Kaoru ; Suzuki, Katsuhiko ; Yoshitani, Kayo ; Shiraishi, Koso ; Kometani, Takashi. / IL-17, neutrophil activation and muscle damage following endurance exercise. In: Exercise Immunology Review. 2012 ; Vol. 18. pp. 116-127.
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