Immobilization of hydrophilic low molecular-weight molecules in nanoparticles of chitosan/poly(sodium 4-styrenesulfonate) assisted by aromatic-aromatic interactions

Juan Pablo Fuenzalida, Mario E. Flores, Inés Móniz, Miguel Feijoo, Francisco Goycoolea, Hiroyuki Nishide, Ignacio Moreno-Villoslada

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Abstract

    The immobilization of the hydrophilic low molecular-weight cationic molecules rhodamine 6G, methylene blue, and citidine in nanoparticles composed of two opposite charged polyelectrolytes, poly(sodium 4-styrenesulfonate) and chitosan, is studied, and the results correlated with their physicochemical properties. Nanoparticles containing both polyelectrolytes have been synthesized showing hydrodynamic diameters of around 200 nm and tunable zeta potential. It was found that the strength of binding of the cationic molecules to the polyanion bearing charged aromatic groups poly(sodium 4-styrenesulfonate) by means of short-range aromatic-aromatic interactions increases with their hydrophobicity and polarizability, as seen by 1H NMR and UV-vis spectroscopies, and diafiltration. Consequently, association efficiencies of 45, 21, and 12% have been found for the three molecules, respectively, revealing the different ability of the molecules to be immobilized in the nanoparticles. These results provide a proof of concept on a new strategy of immobilization of hydrophilic low molecular-weight molecules based on aromatic-aromatic interactions between polyelectrolytes and their aromatic counterions.

    Original languageEnglish
    Pages (from-to)9782-9791
    Number of pages10
    JournalJournal of Physical Chemistry B
    Volume118
    Issue number32
    DOIs
    Publication statusPublished - 2014 Aug 14

    ASJC Scopus subject areas

    • Physical and Theoretical Chemistry
    • Materials Chemistry
    • Surfaces, Coatings and Films

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