Immobilization on the day 14th does not disrupts the basic diurnal rhythm of bone resorption.

C. S. Kim, Y. Maekawa, M. Fujita, N. Sato, M. Nishimuta, Y. Ishizaki, F. Ohta, H. Fukuoka

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Weight bearing and physical activity are important mechanical stimuli to bone growth and metabolism, and microgravity, such a space flight and/or bed rest, induces bone resorption and bone loss. An increased excretion of urinary Ca, an increased bone resorption and a decreased bone mineral density (BMD) have been observed in bed rest experiment of healthy subjects. Bone resorption markers show the specific circadian rhythms in human. Cross-linked carboxyl-terminal telopeptide of type I collagen (ICTP) and the urinary excretion of deoxypyridinoline (Dpy) are the highest in the early morning and the lowest late at night. Bed rest immobilization might influence these rhythms, due to no mechanical loading with loss of daily life activity. Bone resorption markers in healthy subjects had been compared between before and during bed rest to determine disruption of diurnal rhythms of bone resorption.

Original languageEnglish
JournalJournal of gravitational physiology : a journal of the International Society for Gravitational Physiology
Volume7
Issue number2
Publication statusPublished - 2000

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Bone Resorption
Circadian Rhythm
Bed Rest
Immobilization
Healthy Volunteers
Weightlessness
Space Flight
Bone Development
Weight-Bearing
Collagen Type I
Bone Density
Exercise
Bone and Bones

Cite this

Immobilization on the day 14th does not disrupts the basic diurnal rhythm of bone resorption. / Kim, C. S.; Maekawa, Y.; Fujita, M.; Sato, N.; Nishimuta, M.; Ishizaki, Y.; Ohta, F.; Fukuoka, H.

In: Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology, Vol. 7, No. 2, 2000.

Research output: Contribution to journalArticle

Kim, C. S. ; Maekawa, Y. ; Fujita, M. ; Sato, N. ; Nishimuta, M. ; Ishizaki, Y. ; Ohta, F. ; Fukuoka, H. / Immobilization on the day 14th does not disrupts the basic diurnal rhythm of bone resorption. In: Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology. 2000 ; Vol. 7, No. 2.
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