Improvement in long-term stability of field effect transistor biosensor in aqueous environments using a combination of silane and reduced graphene oxide coating

Sho Hideshima*, Hiroki Hayashi, Ryo Takeuchi, Shofarul Wustoni, Shigeki Kuroiwa, Takuya Nakanishi, Toshiyuki Momma, Tetsuya Osaka

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A field-effect transistor (FET) biosensor that can directly detect target molecules is a promising diagnostic tool for healthcare and medical applications. However, the immersion of FET sensors in aqueous physiological environments for the long-term stability might damage the insulating layer of silicon dioxide, resulting in the degradation of the sensor response reproducibility. In this study, to improve the durability of the sensor response for long-term immersion in aqueous solution, we examined the effectiveness of reduced graphene oxide (rGO) coating on the gate insulator of FET sensors. The rGO coating was applied to the gate surface of the FET biosensor modified with an amino-terminated self-assembled monolayer by two steps: deposition of graphene oxide (GO) dispersion onto the monolayer-modified surface and subsequent thermal reduction of GO. The transconductance of both GO-coated and rGO-coated FETs remained unchanged after incubation under physiological conditions, suggesting that graphene prevents cations in the electrolytes from invading the gate insulator of the FET. Furthermore, functionalizing the rGO-coated FET surface enabled specific detection of target molecule.

Original languageEnglish
Article number111859
JournalMicroelectronic Engineering
Volume264
DOIs
Publication statusPublished - 2022 Aug 15

Keywords

  • Field effect transistor biosensors
  • Long-term stability
  • Physiological environment
  • Reduced graphene oxide
  • Self-assembled monolayer

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Electrical and Electronic Engineering

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