Abstract
Strong scattering in turbid medium is a severe difficulty for optical imaging and measurement in an animal body. Therefore, the suppression of scattering effect is crucially important in many applications of biomedical optics. In the optical transillumination imaging of an animal body, this effect appears as strong blurring of the image. This blurring poses a fundamentally important difficulty restricting the practical application of transillumination imaging. Therefore, we have attempted to suppress scattering effect using the time-reversal ability of phase-conjugate light. For our previous study, we constructed a digital system to generate light not only with conjugated phase but also with the same intensity distribution as non-scattered signal light. Using this system, we were able to restore the pattern of incident light from the blurred image because of time-reversal propagation of the phase-conjugate light. In comparison to a case with phase information only, we found that addition of the intensity information greatly improves the scattering suppression capability of the time-reversal principle. However, our pilot study showed this ability was valid only for the scattering medium with the optical distance OD less than 1. This report describes the improvement of our measurement system to make the scattering suppression possible for turbid media with OD of more than 1 using a light source with a longer coherence length. Scattering suppression was effective for spatial frequencies of 0.4-1.0 lp/mm through the scattering medium up to OD=1.8.
| Original language | English |
|---|---|
| Title of host publication | Adaptive Optics and Wavefront Control for Biological Systems V |
| Editors | Na Ji, Thomas G. Bifano, Sylvain Gigan |
| Publisher | SPIE |
| ISBN (Electronic) | 9781510624146 |
| DOIs | |
| Publication status | Published - 2019 Jan 1 |
| Event | Adaptive Optics and Wavefront Control for Biological Systems V 2019 - San Francisco, United States Duration: 2019 Feb 3 → 2019 Feb 4 |
Publication series
| Name | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
|---|---|
| Volume | 10886 |
| ISSN (Print) | 1605-7422 |
Conference
| Conference | Adaptive Optics and Wavefront Control for Biological Systems V 2019 |
|---|---|
| Country | United States |
| City | San Francisco |
| Period | 19/2/3 → 19/2/4 |
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Keywords
- Biological imaging
- Digital phase-conjugate light
- Imaging through turbid media
- Intensity modulation
- Optical scattering
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
- Biomaterials
- Radiology Nuclear Medicine and imaging
Cite this
Improvement of scattering suppression effect of time-reversal propagation using digital phase-conjugate light. / Toda, Sogo; Kato, Yuji; Kudo, Nobuki; Shimizu, Koichi.
Adaptive Optics and Wavefront Control for Biological Systems V. ed. / Na Ji; Thomas G. Bifano; Sylvain Gigan. SPIE, 2019. 1088613 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10886).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Improvement of scattering suppression effect of time-reversal propagation using digital phase-conjugate light
AU - Toda, Sogo
AU - Kato, Yuji
AU - Kudo, Nobuki
AU - Shimizu, Koichi
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Strong scattering in turbid medium is a severe difficulty for optical imaging and measurement in an animal body. Therefore, the suppression of scattering effect is crucially important in many applications of biomedical optics. In the optical transillumination imaging of an animal body, this effect appears as strong blurring of the image. This blurring poses a fundamentally important difficulty restricting the practical application of transillumination imaging. Therefore, we have attempted to suppress scattering effect using the time-reversal ability of phase-conjugate light. For our previous study, we constructed a digital system to generate light not only with conjugated phase but also with the same intensity distribution as non-scattered signal light. Using this system, we were able to restore the pattern of incident light from the blurred image because of time-reversal propagation of the phase-conjugate light. In comparison to a case with phase information only, we found that addition of the intensity information greatly improves the scattering suppression capability of the time-reversal principle. However, our pilot study showed this ability was valid only for the scattering medium with the optical distance OD less than 1. This report describes the improvement of our measurement system to make the scattering suppression possible for turbid media with OD of more than 1 using a light source with a longer coherence length. Scattering suppression was effective for spatial frequencies of 0.4-1.0 lp/mm through the scattering medium up to OD=1.8.
AB - Strong scattering in turbid medium is a severe difficulty for optical imaging and measurement in an animal body. Therefore, the suppression of scattering effect is crucially important in many applications of biomedical optics. In the optical transillumination imaging of an animal body, this effect appears as strong blurring of the image. This blurring poses a fundamentally important difficulty restricting the practical application of transillumination imaging. Therefore, we have attempted to suppress scattering effect using the time-reversal ability of phase-conjugate light. For our previous study, we constructed a digital system to generate light not only with conjugated phase but also with the same intensity distribution as non-scattered signal light. Using this system, we were able to restore the pattern of incident light from the blurred image because of time-reversal propagation of the phase-conjugate light. In comparison to a case with phase information only, we found that addition of the intensity information greatly improves the scattering suppression capability of the time-reversal principle. However, our pilot study showed this ability was valid only for the scattering medium with the optical distance OD less than 1. This report describes the improvement of our measurement system to make the scattering suppression possible for turbid media with OD of more than 1 using a light source with a longer coherence length. Scattering suppression was effective for spatial frequencies of 0.4-1.0 lp/mm through the scattering medium up to OD=1.8.
KW - Biological imaging
KW - Digital phase-conjugate light
KW - Imaging through turbid media
KW - Intensity modulation
KW - Optical scattering
UR - http://www.scopus.com/inward/record.url?scp=85066629738&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85066629738&partnerID=8YFLogxK
U2 - 10.1117/12.2505213
DO - 10.1117/12.2505213
M3 - Conference contribution
AN - SCOPUS:85066629738
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Adaptive Optics and Wavefront Control for Biological Systems V
A2 - Ji, Na
A2 - Bifano, Thomas G.
A2 - Gigan, Sylvain
PB - SPIE
ER -