Abstract
The size-selective microfluidic separation of glass beads in a curved rectangular microchannel was fabricated in our previous work. In this study, we improve its separation performance and attempt an experimental visualization to examine the separation resolution. In the previous work, we found by visualization that the trajectory of 20μm glass beads was influenced by their travelling path along a straight inlet channel. Using a forced sheath flow, a consistent bead trajectory along the middle of the straight inlet channel was obtained, and the sheath angle to minimize the focusing width of the flowing distributed beads was determined to be 45°. The physical explanation for the dynamic behavior of microbeads was elaborated. When the ratio of Stokes force to centrifugal force mainly acting on a glass bead fell under unity, the glass bead moved out to the wall in spite of the fact that its size was less than the height of the zero velocity position. To examine the separation resolution, the newly designed size-selective separation microchannel with the sheath was fabricated and its separation performance was visualized. The movement of the glass beads showed a good agreement with the separation mechanism explained by the force ratio. The resolution of the separation was visualized to be 10μm for the size of glass beads used in the experiment. The size-selective separation performance was explained in terms of physical forces and was improved by solving the previous problems. A cascade device for the continuous separation of microbeads of various sizes can improve the separation resolution.
| Original language | English |
|---|---|
| Article number | 097301 |
| Journal | Japanese Journal of Applied Physics |
| Volume | 50 |
| Issue number | 9 PART 1 |
| DOIs | |
| Publication status | Published - 2011 Sep |
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ASJC Scopus subject areas
- Engineering(all)
- Physics and Astronomy(all)
Cite this
Improvement of the size-selective separation of microbeads in a curved microchannel using particle focusing. / Kwon, Bong Hyun; Kim, Hyung Hoon; Cha, Jemyung; Ahn, Cheol Hee; Arakawa, Takahiro; Shoji, Shuichi; Go, Jeung Sang.
In: Japanese Journal of Applied Physics, Vol. 50, No. 9 PART 1, 097301, 09.2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Improvement of the size-selective separation of microbeads in a curved microchannel using particle focusing
AU - Kwon, Bong Hyun
AU - Kim, Hyung Hoon
AU - Cha, Jemyung
AU - Ahn, Cheol Hee
AU - Arakawa, Takahiro
AU - Shoji, Shuichi
AU - Go, Jeung Sang
PY - 2011/9
Y1 - 2011/9
N2 - The size-selective microfluidic separation of glass beads in a curved rectangular microchannel was fabricated in our previous work. In this study, we improve its separation performance and attempt an experimental visualization to examine the separation resolution. In the previous work, we found by visualization that the trajectory of 20μm glass beads was influenced by their travelling path along a straight inlet channel. Using a forced sheath flow, a consistent bead trajectory along the middle of the straight inlet channel was obtained, and the sheath angle to minimize the focusing width of the flowing distributed beads was determined to be 45°. The physical explanation for the dynamic behavior of microbeads was elaborated. When the ratio of Stokes force to centrifugal force mainly acting on a glass bead fell under unity, the glass bead moved out to the wall in spite of the fact that its size was less than the height of the zero velocity position. To examine the separation resolution, the newly designed size-selective separation microchannel with the sheath was fabricated and its separation performance was visualized. The movement of the glass beads showed a good agreement with the separation mechanism explained by the force ratio. The resolution of the separation was visualized to be 10μm for the size of glass beads used in the experiment. The size-selective separation performance was explained in terms of physical forces and was improved by solving the previous problems. A cascade device for the continuous separation of microbeads of various sizes can improve the separation resolution.
AB - The size-selective microfluidic separation of glass beads in a curved rectangular microchannel was fabricated in our previous work. In this study, we improve its separation performance and attempt an experimental visualization to examine the separation resolution. In the previous work, we found by visualization that the trajectory of 20μm glass beads was influenced by their travelling path along a straight inlet channel. Using a forced sheath flow, a consistent bead trajectory along the middle of the straight inlet channel was obtained, and the sheath angle to minimize the focusing width of the flowing distributed beads was determined to be 45°. The physical explanation for the dynamic behavior of microbeads was elaborated. When the ratio of Stokes force to centrifugal force mainly acting on a glass bead fell under unity, the glass bead moved out to the wall in spite of the fact that its size was less than the height of the zero velocity position. To examine the separation resolution, the newly designed size-selective separation microchannel with the sheath was fabricated and its separation performance was visualized. The movement of the glass beads showed a good agreement with the separation mechanism explained by the force ratio. The resolution of the separation was visualized to be 10μm for the size of glass beads used in the experiment. The size-selective separation performance was explained in terms of physical forces and was improved by solving the previous problems. A cascade device for the continuous separation of microbeads of various sizes can improve the separation resolution.
UR - http://www.scopus.com/inward/record.url?scp=80053046670&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053046670&partnerID=8YFLogxK
U2 - 10.1143/JJAP.50.097301
DO - 10.1143/JJAP.50.097301
M3 - Article
AN - SCOPUS:80053046670
VL - 50
JO - Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes
JF - Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes
SN - 0021-4922
IS - 9 PART 1
M1 - 097301
ER -