Improvement of the size-selective separation of microbeads in a curved microchannel using particle focusing

Bong Hyun Kwon, Hyung Hoon Kim, Jemyung Cha, Cheol Hee Ahn, Takahiro Arakawa, Shuichi Shoji, Jeung Sang Go

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    The size-selective microfluidic separation of glass beads in a curved rectangular microchannel was fabricated in our previous work. In this study, we improve its separation performance and attempt an experimental visualization to examine the separation resolution. In the previous work, we found by visualization that the trajectory of 20μm glass beads was influenced by their travelling path along a straight inlet channel. Using a forced sheath flow, a consistent bead trajectory along the middle of the straight inlet channel was obtained, and the sheath angle to minimize the focusing width of the flowing distributed beads was determined to be 45°. The physical explanation for the dynamic behavior of microbeads was elaborated. When the ratio of Stokes force to centrifugal force mainly acting on a glass bead fell under unity, the glass bead moved out to the wall in spite of the fact that its size was less than the height of the zero velocity position. To examine the separation resolution, the newly designed size-selective separation microchannel with the sheath was fabricated and its separation performance was visualized. The movement of the glass beads showed a good agreement with the separation mechanism explained by the force ratio. The resolution of the separation was visualized to be 10μm for the size of glass beads used in the experiment. The size-selective separation performance was explained in terms of physical forces and was improved by solving the previous problems. A cascade device for the continuous separation of microbeads of various sizes can improve the separation resolution.

    Original languageEnglish
    Article number097301
    JournalJapanese Journal of Applied Physics
    Volume50
    Issue number9 PART 1
    DOIs
    Publication statusPublished - 2011 Sep

    Fingerprint

    microchannels
    Microchannels
    beads
    Glass
    glass
    sheaths
    Visualization
    Trajectories
    trajectories
    centrifugal force
    Microfluidics
    unity
    cascades

    ASJC Scopus subject areas

    • Engineering(all)
    • Physics and Astronomy(all)

    Cite this

    Improvement of the size-selective separation of microbeads in a curved microchannel using particle focusing. / Kwon, Bong Hyun; Kim, Hyung Hoon; Cha, Jemyung; Ahn, Cheol Hee; Arakawa, Takahiro; Shoji, Shuichi; Go, Jeung Sang.

    In: Japanese Journal of Applied Physics, Vol. 50, No. 9 PART 1, 097301, 09.2011.

    Research output: Contribution to journalArticle

    Kwon, Bong Hyun ; Kim, Hyung Hoon ; Cha, Jemyung ; Ahn, Cheol Hee ; Arakawa, Takahiro ; Shoji, Shuichi ; Go, Jeung Sang. / Improvement of the size-selective separation of microbeads in a curved microchannel using particle focusing. In: Japanese Journal of Applied Physics. 2011 ; Vol. 50, No. 9 PART 1.
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