In-situ real-time monitoring of volatile organic compound exposure and heart rate variability for patients with multiple chemical sensitivity

Atsushi Mizukoshi, Kazukiyo Kumagai, Naomichi Yamamoto, Miyuki Noguchi, Kazuhiro Yoshiuchi, Hiroaki Kumano, Kou Sakabe, Yukio Yanagisawa

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    In-situ real-time monitoring of volatile organic compound (VOC) exposure and heart rate variability (HRV) were conducted for eight multiple chemical sensitivity (MCS) patients using a VOC monitor, a Holter monitor, and a time-activity questionnaire for 24 h to identify the relationship between VOC exposure, biological effects, and subjective symptoms in actual life. The results revealed no significantly different parameters for averaged values such as VOC concentration, HF (high frequency), and LF (low frequency) to HF ratio compared with previous data from healthy subjects (Int. J. Environ. Res. Public Health 2010, 7, 4127–4138). Significant negative correlations for four subjects were observed between HF and amounts of VOC change. These results suggest that some patients show inhibition of parasympathetic activities along with VOC exposure as observed in healthy subjects. Comparing the parameters during subjective symptoms and normal condition, VOC concentration and/or VOC change were high except for one subject. HF values were low for five subjects during subjective symptoms. Examining the time-series data for VOC exposure and HF of each subject showed that the subjective symptoms, VOC exposure, and HF seemed well related in some symptoms. Based on these characteristics, prevention measures of symptoms for each subject may be proposed.

    Original languageEnglish
    Pages (from-to)12446-12465
    Number of pages20
    JournalInternational Journal of Environmental Research and Public Health
    Volume12
    Issue number10
    DOIs
    Publication statusPublished - 2015 Oct 5

    Fingerprint

    Multiple Chemical Sensitivity
    Volatile Organic Compounds
    Heart Rate
    Healthy Volunteers
    Public Health

    Keywords

    • HRV
    • MCS
    • Real-time monitoring
    • VOC

    ASJC Scopus subject areas

    • Public Health, Environmental and Occupational Health
    • Health, Toxicology and Mutagenesis

    Cite this

    In-situ real-time monitoring of volatile organic compound exposure and heart rate variability for patients with multiple chemical sensitivity. / Mizukoshi, Atsushi; Kumagai, Kazukiyo; Yamamoto, Naomichi; Noguchi, Miyuki; Yoshiuchi, Kazuhiro; Kumano, Hiroaki; Sakabe, Kou; Yanagisawa, Yukio.

    In: International Journal of Environmental Research and Public Health, Vol. 12, No. 10, 05.10.2015, p. 12446-12465.

    Research output: Contribution to journalArticle

    Mizukoshi, Atsushi ; Kumagai, Kazukiyo ; Yamamoto, Naomichi ; Noguchi, Miyuki ; Yoshiuchi, Kazuhiro ; Kumano, Hiroaki ; Sakabe, Kou ; Yanagisawa, Yukio. / In-situ real-time monitoring of volatile organic compound exposure and heart rate variability for patients with multiple chemical sensitivity. In: International Journal of Environmental Research and Public Health. 2015 ; Vol. 12, No. 10. pp. 12446-12465.
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