Abstract
In-situ real-time monitoring of volatile organic compound (VOC) exposure and heart rate variability (HRV) were conducted for eight multiple chemical sensitivity (MCS) patients using a VOC monitor, a Holter monitor, and a time-activity questionnaire for 24 h to identify the relationship between VOC exposure, biological effects, and subjective symptoms in actual life. The results revealed no significantly different parameters for averaged values such as VOC concentration, HF (high frequency), and LF (low frequency) to HF ratio compared with previous data from healthy subjects (Int. J. Environ. Res. Public Health 2010, 7, 4127–4138). Significant negative correlations for four subjects were observed between HF and amounts of VOC change. These results suggest that some patients show inhibition of parasympathetic activities along with VOC exposure as observed in healthy subjects. Comparing the parameters during subjective symptoms and normal condition, VOC concentration and/or VOC change were high except for one subject. HF values were low for five subjects during subjective symptoms. Examining the time-series data for VOC exposure and HF of each subject showed that the subjective symptoms, VOC exposure, and HF seemed well related in some symptoms. Based on these characteristics, prevention measures of symptoms for each subject may be proposed.
| Original language | English |
|---|---|
| Pages (from-to) | 12446-12465 |
| Number of pages | 20 |
| Journal | International Journal of Environmental Research and Public Health |
| Volume | 12 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2015 Oct 5 |
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Keywords
- HRV
- MCS
- Real-time monitoring
- VOC
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis
Cite this
In-situ real-time monitoring of volatile organic compound exposure and heart rate variability for patients with multiple chemical sensitivity. / Mizukoshi, Atsushi; Kumagai, Kazukiyo; Yamamoto, Naomichi; Noguchi, Miyuki; Yoshiuchi, Kazuhiro; Kumano, Hiroaki; Sakabe, Kou; Yanagisawa, Yukio.
In: International Journal of Environmental Research and Public Health, Vol. 12, No. 10, 05.10.2015, p. 12446-12465.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In-situ real-time monitoring of volatile organic compound exposure and heart rate variability for patients with multiple chemical sensitivity
AU - Mizukoshi, Atsushi
AU - Kumagai, Kazukiyo
AU - Yamamoto, Naomichi
AU - Noguchi, Miyuki
AU - Yoshiuchi, Kazuhiro
AU - Kumano, Hiroaki
AU - Sakabe, Kou
AU - Yanagisawa, Yukio
PY - 2015/10/5
Y1 - 2015/10/5
N2 - In-situ real-time monitoring of volatile organic compound (VOC) exposure and heart rate variability (HRV) were conducted for eight multiple chemical sensitivity (MCS) patients using a VOC monitor, a Holter monitor, and a time-activity questionnaire for 24 h to identify the relationship between VOC exposure, biological effects, and subjective symptoms in actual life. The results revealed no significantly different parameters for averaged values such as VOC concentration, HF (high frequency), and LF (low frequency) to HF ratio compared with previous data from healthy subjects (Int. J. Environ. Res. Public Health 2010, 7, 4127–4138). Significant negative correlations for four subjects were observed between HF and amounts of VOC change. These results suggest that some patients show inhibition of parasympathetic activities along with VOC exposure as observed in healthy subjects. Comparing the parameters during subjective symptoms and normal condition, VOC concentration and/or VOC change were high except for one subject. HF values were low for five subjects during subjective symptoms. Examining the time-series data for VOC exposure and HF of each subject showed that the subjective symptoms, VOC exposure, and HF seemed well related in some symptoms. Based on these characteristics, prevention measures of symptoms for each subject may be proposed.
AB - In-situ real-time monitoring of volatile organic compound (VOC) exposure and heart rate variability (HRV) were conducted for eight multiple chemical sensitivity (MCS) patients using a VOC monitor, a Holter monitor, and a time-activity questionnaire for 24 h to identify the relationship between VOC exposure, biological effects, and subjective symptoms in actual life. The results revealed no significantly different parameters for averaged values such as VOC concentration, HF (high frequency), and LF (low frequency) to HF ratio compared with previous data from healthy subjects (Int. J. Environ. Res. Public Health 2010, 7, 4127–4138). Significant negative correlations for four subjects were observed between HF and amounts of VOC change. These results suggest that some patients show inhibition of parasympathetic activities along with VOC exposure as observed in healthy subjects. Comparing the parameters during subjective symptoms and normal condition, VOC concentration and/or VOC change were high except for one subject. HF values were low for five subjects during subjective symptoms. Examining the time-series data for VOC exposure and HF of each subject showed that the subjective symptoms, VOC exposure, and HF seemed well related in some symptoms. Based on these characteristics, prevention measures of symptoms for each subject may be proposed.
KW - HRV
KW - MCS
KW - Real-time monitoring
KW - VOC
UR - http://www.scopus.com/inward/record.url?scp=84943558194&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84943558194&partnerID=8YFLogxK
U2 - 10.3390/ijerph121012446
DO - 10.3390/ijerph121012446
M3 - Article
C2 - 26445055
AN - SCOPUS:84943558194
VL - 12
SP - 12446
EP - 12465
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
SN - 1661-7827
IS - 10
ER -