In-vitro evaluation of coronary stents

Mitsuo Umezu, Y. Horikiri, Kiyotaka Iwasaki, T. Fujimoto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In-vitro evaluation of various kinds of clinically available coronary stents has been performed in order to establish a standard test methodology. First, a silicone tube with an internal diameter of 3 mm was fabricated as a model for the coronary artery. The model provides an equivalent Young's modulus to the natural vessel. Then, changes in the ratio of the stent diameter (elastic recoil) were measured after deflation of an inserted balloon. Radial changes caused by external pressure on the tube were also measured (radial strength). As a result, elastic recoil remained within 6% at the maximum, and radial strength decreased linearly with a range of 0-200 mmHg. The maximum of radial strength was 5% at 200 mmHg. Secondly, an artificial coronary circuit was developed and installed into a pulsatile flow-type mock circulatory system, where arterial pressure and flow waveforms could be reproduced that were similar to those of the human coronary arteries. The pulsatile flow test revealed that a subsequent change in stent diameter was achieved by a change in a pulsatile coronary flow. However, the maximum change amounted to only 1.5% in the radial direction.

Original languageEnglish
Pages (from-to)99-104
Number of pages6
JournalJapanese Journal of Artificial Organs
Volume29
Issue number1
Publication statusPublished - 2000

Fingerprint

Pulsatile Flow
Stents
Coronary Vessels
Elastic Modulus
Silicones
Cardiovascular System
Arterial Pressure
Pressure
In Vitro Techniques

Keywords

  • Coronary circulation
  • Coronary stent
  • Delivery balloon catheter
  • Elastic recoil
  • in-vitro testing
  • Radial strength

ASJC Scopus subject areas

  • Biophysics

Cite this

In-vitro evaluation of coronary stents. / Umezu, Mitsuo; Horikiri, Y.; Iwasaki, Kiyotaka; Fujimoto, T.

In: Japanese Journal of Artificial Organs, Vol. 29, No. 1, 2000, p. 99-104.

Research output: Contribution to journalArticle

Umezu, M, Horikiri, Y, Iwasaki, K & Fujimoto, T 2000, 'In-vitro evaluation of coronary stents', Japanese Journal of Artificial Organs, vol. 29, no. 1, pp. 99-104.
Umezu, Mitsuo ; Horikiri, Y. ; Iwasaki, Kiyotaka ; Fujimoto, T. / In-vitro evaluation of coronary stents. In: Japanese Journal of Artificial Organs. 2000 ; Vol. 29, No. 1. pp. 99-104.
@article{0a100ef1c90b44c4bc08397631c5471a,
title = "In-vitro evaluation of coronary stents",
abstract = "In-vitro evaluation of various kinds of clinically available coronary stents has been performed in order to establish a standard test methodology. First, a silicone tube with an internal diameter of 3 mm was fabricated as a model for the coronary artery. The model provides an equivalent Young's modulus to the natural vessel. Then, changes in the ratio of the stent diameter (elastic recoil) were measured after deflation of an inserted balloon. Radial changes caused by external pressure on the tube were also measured (radial strength). As a result, elastic recoil remained within 6{\%} at the maximum, and radial strength decreased linearly with a range of 0-200 mmHg. The maximum of radial strength was 5{\%} at 200 mmHg. Secondly, an artificial coronary circuit was developed and installed into a pulsatile flow-type mock circulatory system, where arterial pressure and flow waveforms could be reproduced that were similar to those of the human coronary arteries. The pulsatile flow test revealed that a subsequent change in stent diameter was achieved by a change in a pulsatile coronary flow. However, the maximum change amounted to only 1.5{\%} in the radial direction.",
keywords = "Coronary circulation, Coronary stent, Delivery balloon catheter, Elastic recoil, in-vitro testing, Radial strength",
author = "Mitsuo Umezu and Y. Horikiri and Kiyotaka Iwasaki and T. Fujimoto",
year = "2000",
language = "English",
volume = "29",
pages = "99--104",
journal = "Japanese Journal of Artificial Organs",
issn = "0300-0818",
publisher = "Japanese Society for Artificial Organs and Tissues",
number = "1",

}

TY - JOUR

T1 - In-vitro evaluation of coronary stents

AU - Umezu, Mitsuo

AU - Horikiri, Y.

AU - Iwasaki, Kiyotaka

AU - Fujimoto, T.

PY - 2000

Y1 - 2000

N2 - In-vitro evaluation of various kinds of clinically available coronary stents has been performed in order to establish a standard test methodology. First, a silicone tube with an internal diameter of 3 mm was fabricated as a model for the coronary artery. The model provides an equivalent Young's modulus to the natural vessel. Then, changes in the ratio of the stent diameter (elastic recoil) were measured after deflation of an inserted balloon. Radial changes caused by external pressure on the tube were also measured (radial strength). As a result, elastic recoil remained within 6% at the maximum, and radial strength decreased linearly with a range of 0-200 mmHg. The maximum of radial strength was 5% at 200 mmHg. Secondly, an artificial coronary circuit was developed and installed into a pulsatile flow-type mock circulatory system, where arterial pressure and flow waveforms could be reproduced that were similar to those of the human coronary arteries. The pulsatile flow test revealed that a subsequent change in stent diameter was achieved by a change in a pulsatile coronary flow. However, the maximum change amounted to only 1.5% in the radial direction.

AB - In-vitro evaluation of various kinds of clinically available coronary stents has been performed in order to establish a standard test methodology. First, a silicone tube with an internal diameter of 3 mm was fabricated as a model for the coronary artery. The model provides an equivalent Young's modulus to the natural vessel. Then, changes in the ratio of the stent diameter (elastic recoil) were measured after deflation of an inserted balloon. Radial changes caused by external pressure on the tube were also measured (radial strength). As a result, elastic recoil remained within 6% at the maximum, and radial strength decreased linearly with a range of 0-200 mmHg. The maximum of radial strength was 5% at 200 mmHg. Secondly, an artificial coronary circuit was developed and installed into a pulsatile flow-type mock circulatory system, where arterial pressure and flow waveforms could be reproduced that were similar to those of the human coronary arteries. The pulsatile flow test revealed that a subsequent change in stent diameter was achieved by a change in a pulsatile coronary flow. However, the maximum change amounted to only 1.5% in the radial direction.

KW - Coronary circulation

KW - Coronary stent

KW - Delivery balloon catheter

KW - Elastic recoil

KW - in-vitro testing

KW - Radial strength

UR - http://www.scopus.com/inward/record.url?scp=29344460650&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=29344460650&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:29344460650

VL - 29

SP - 99

EP - 104

JO - Japanese Journal of Artificial Organs

JF - Japanese Journal of Artificial Organs

SN - 0300-0818

IS - 1

ER -