In vitro laser Doppler anemometry of pulsatile flow velocity and shear stress measurements downstream from a jellyfish valve in the mitral position of a ventricular assist device

Yos Morsi, Masahisa Kogure, Mitsuo Umezu

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    Thrombus formation and hemolysis have both been linked to the dynamic flow characteristics of heart valve prostheses. To enhance our understanding of the flow characteristics past the mitral position of a jellyfish (JF) valve in the left ventricle under physiological pulsatile flow conditions, in vitro laser Doppler anemometry (LDA) measurements were carried out. The hydrodynamic performance of the JF valve was compared with that of a Bjork-Shiley tilting-disk valve (BS mono). The results indicated that both valves created disturbed flow fields and turbulence shear stress levels in the immediate vicinity and up to 1D (diameter of the valvering) downstream from the valve that were capable of causing lethal damage to blood elements. At a location further downstream, the JF valve showed better hydrodynamic performance than the BS in terms of back flow properties and velocity and turbulence stress characteristics. However, any imperfection in the manufacturing of the valve structure, particularly membrane thickness, adversely affected the performance of the JF valve.

    Original languageEnglish
    Pages (from-to)62-73
    Number of pages12
    JournalJournal of Artificial Organs
    Volume2
    Issue number1
    DOIs
    Publication statusPublished - 1999

    Fingerprint

    Pulsatile Flow
    Pulsatile flow
    Heart-Assist Devices
    Stress measurement
    Hydrodynamics
    Mitral Valve
    Flow velocity
    Shear stress
    Lasers
    Turbulence
    Heart valve prostheses
    Heart Valve Prosthesis
    Membrane structures
    Hemolysis
    Heart Ventricles
    Flow fields
    Thrombosis
    Blood
    Defects
    Membranes

    Keywords

    • Artificial heart valve
    • Hydrodynamics
    • Mitral position
    • Pulsatile flow

    ASJC Scopus subject areas

    • Biophysics

    Cite this

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    title = "In vitro laser Doppler anemometry of pulsatile flow velocity and shear stress measurements downstream from a jellyfish valve in the mitral position of a ventricular assist device",
    abstract = "Thrombus formation and hemolysis have both been linked to the dynamic flow characteristics of heart valve prostheses. To enhance our understanding of the flow characteristics past the mitral position of a jellyfish (JF) valve in the left ventricle under physiological pulsatile flow conditions, in vitro laser Doppler anemometry (LDA) measurements were carried out. The hydrodynamic performance of the JF valve was compared with that of a Bjork-Shiley tilting-disk valve (BS mono). The results indicated that both valves created disturbed flow fields and turbulence shear stress levels in the immediate vicinity and up to 1D (diameter of the valvering) downstream from the valve that were capable of causing lethal damage to blood elements. At a location further downstream, the JF valve showed better hydrodynamic performance than the BS in terms of back flow properties and velocity and turbulence stress characteristics. However, any imperfection in the manufacturing of the valve structure, particularly membrane thickness, adversely affected the performance of the JF valve.",
    keywords = "Artificial heart valve, Hydrodynamics, Mitral position, Pulsatile flow",
    author = "Yos Morsi and Masahisa Kogure and Mitsuo Umezu",
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    T1 - In vitro laser Doppler anemometry of pulsatile flow velocity and shear stress measurements downstream from a jellyfish valve in the mitral position of a ventricular assist device

    AU - Morsi, Yos

    AU - Kogure, Masahisa

    AU - Umezu, Mitsuo

    PY - 1999

    Y1 - 1999

    N2 - Thrombus formation and hemolysis have both been linked to the dynamic flow characteristics of heart valve prostheses. To enhance our understanding of the flow characteristics past the mitral position of a jellyfish (JF) valve in the left ventricle under physiological pulsatile flow conditions, in vitro laser Doppler anemometry (LDA) measurements were carried out. The hydrodynamic performance of the JF valve was compared with that of a Bjork-Shiley tilting-disk valve (BS mono). The results indicated that both valves created disturbed flow fields and turbulence shear stress levels in the immediate vicinity and up to 1D (diameter of the valvering) downstream from the valve that were capable of causing lethal damage to blood elements. At a location further downstream, the JF valve showed better hydrodynamic performance than the BS in terms of back flow properties and velocity and turbulence stress characteristics. However, any imperfection in the manufacturing of the valve structure, particularly membrane thickness, adversely affected the performance of the JF valve.

    AB - Thrombus formation and hemolysis have both been linked to the dynamic flow characteristics of heart valve prostheses. To enhance our understanding of the flow characteristics past the mitral position of a jellyfish (JF) valve in the left ventricle under physiological pulsatile flow conditions, in vitro laser Doppler anemometry (LDA) measurements were carried out. The hydrodynamic performance of the JF valve was compared with that of a Bjork-Shiley tilting-disk valve (BS mono). The results indicated that both valves created disturbed flow fields and turbulence shear stress levels in the immediate vicinity and up to 1D (diameter of the valvering) downstream from the valve that were capable of causing lethal damage to blood elements. At a location further downstream, the JF valve showed better hydrodynamic performance than the BS in terms of back flow properties and velocity and turbulence stress characteristics. However, any imperfection in the manufacturing of the valve structure, particularly membrane thickness, adversely affected the performance of the JF valve.

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    KW - Mitral position

    KW - Pulsatile flow

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