In vivo assessment of novel stentless valve in the mitral position

Satoshi Kainuma, Hitoshi Kasegawa, Shigeru Miyagawa, Hiroyuki Nishi, Hitoshi Yaku, Shuichiro Takanashi, Kazuhiro Hashimoto, Yukikatsu Okada, Satoshi Nakatani, Mitsuo Umezu, Takashi Daimon, Taichi Sakaguchi, Koichi Toda, Yoshiki Sawa

    Research output: Contribution to journalArticle

    Abstract

    Background: We conducted in vivo examinations of a newly designed stentless mitral valve (SMV), formed by suturing 2 leaflets with the “legs” serving as chorda tendinea, made from bovine pericardium, to a flexible ring. Methods and Results: Seven pigs underwent implantation of the SMV constructed with a 23-mm (n=5) or 25-mm (n=2) Duran ring. Baseline echocardiography examinations were used to evaluate the annular anteroposterior diameter, and distance between the mitral annulus (MA) and papillary muscles (PMs) to determine SMV-leg length. After removing the native valve, the SMV-legs were fixed to the anterior and posterior PMs, followed by fixation of the ring to the native MA. Immediately after surgery, all animals presented none or trivial mitral regurgitation, with mean and peak trans-SMV pressure gradient values of 1.9±0.8 and 6.0±3.1 mmHg, respectively. The mean length of the SMV-leg was 19.4±3.9 mm, which correlated with the distance between anterior and posterior MA-PM (r=0.96 and 0.94, respectively, P<0.01 for both). The discrepancy between the anteroposterior diameter of the ring (outside diameter) and that of the native valve was 1.0±2.9 mm, which correlated with the trans-SMV pressure gradient (r=0.81, P=0.025). Conclusions: In our preliminary study, the SMV demonstrated excellent diastolic inflow dynamics and closing function in vivo. Preoperative precise assessment of MV configuration may serve as a basis for selection of appropriate ring size and SMV-leg length.

    Original languageEnglish
    Pages (from-to)553-559
    Number of pages7
    JournalCirculation Journal
    Volume79
    Issue number3
    DOIs
    Publication statusPublished - 2015

    Fingerprint

    Mitral Valve
    Leg
    Papillary Muscles
    Chordae Tendineae
    Pressure
    Pericardium
    Mitral Valve Insufficiency
    Echocardiography
    Swine

    Keywords

    • Animal models
    • Echocardiography
    • Mitral valve

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

    Cite this

    Kainuma, S., Kasegawa, H., Miyagawa, S., Nishi, H., Yaku, H., Takanashi, S., ... Sawa, Y. (2015). In vivo assessment of novel stentless valve in the mitral position. Circulation Journal, 79(3), 553-559. https://doi.org/10.1253/circj.CJ-14-1113

    In vivo assessment of novel stentless valve in the mitral position. / Kainuma, Satoshi; Kasegawa, Hitoshi; Miyagawa, Shigeru; Nishi, Hiroyuki; Yaku, Hitoshi; Takanashi, Shuichiro; Hashimoto, Kazuhiro; Okada, Yukikatsu; Nakatani, Satoshi; Umezu, Mitsuo; Daimon, Takashi; Sakaguchi, Taichi; Toda, Koichi; Sawa, Yoshiki.

    In: Circulation Journal, Vol. 79, No. 3, 2015, p. 553-559.

    Research output: Contribution to journalArticle

    Kainuma, S, Kasegawa, H, Miyagawa, S, Nishi, H, Yaku, H, Takanashi, S, Hashimoto, K, Okada, Y, Nakatani, S, Umezu, M, Daimon, T, Sakaguchi, T, Toda, K & Sawa, Y 2015, 'In vivo assessment of novel stentless valve in the mitral position', Circulation Journal, vol. 79, no. 3, pp. 553-559. https://doi.org/10.1253/circj.CJ-14-1113
    Kainuma S, Kasegawa H, Miyagawa S, Nishi H, Yaku H, Takanashi S et al. In vivo assessment of novel stentless valve in the mitral position. Circulation Journal. 2015;79(3):553-559. https://doi.org/10.1253/circj.CJ-14-1113
    Kainuma, Satoshi ; Kasegawa, Hitoshi ; Miyagawa, Shigeru ; Nishi, Hiroyuki ; Yaku, Hitoshi ; Takanashi, Shuichiro ; Hashimoto, Kazuhiro ; Okada, Yukikatsu ; Nakatani, Satoshi ; Umezu, Mitsuo ; Daimon, Takashi ; Sakaguchi, Taichi ; Toda, Koichi ; Sawa, Yoshiki. / In vivo assessment of novel stentless valve in the mitral position. In: Circulation Journal. 2015 ; Vol. 79, No. 3. pp. 553-559.
    @article{66c63fe7be5244e3a7b9692e9c803499,
    title = "In vivo assessment of novel stentless valve in the mitral position",
    abstract = "Background: We conducted in vivo examinations of a newly designed stentless mitral valve (SMV), formed by suturing 2 leaflets with the “legs” serving as chorda tendinea, made from bovine pericardium, to a flexible ring. Methods and Results: Seven pigs underwent implantation of the SMV constructed with a 23-mm (n=5) or 25-mm (n=2) Duran ring. Baseline echocardiography examinations were used to evaluate the annular anteroposterior diameter, and distance between the mitral annulus (MA) and papillary muscles (PMs) to determine SMV-leg length. After removing the native valve, the SMV-legs were fixed to the anterior and posterior PMs, followed by fixation of the ring to the native MA. Immediately after surgery, all animals presented none or trivial mitral regurgitation, with mean and peak trans-SMV pressure gradient values of 1.9±0.8 and 6.0±3.1 mmHg, respectively. The mean length of the SMV-leg was 19.4±3.9 mm, which correlated with the distance between anterior and posterior MA-PM (r=0.96 and 0.94, respectively, P<0.01 for both). The discrepancy between the anteroposterior diameter of the ring (outside diameter) and that of the native valve was 1.0±2.9 mm, which correlated with the trans-SMV pressure gradient (r=0.81, P=0.025). Conclusions: In our preliminary study, the SMV demonstrated excellent diastolic inflow dynamics and closing function in vivo. Preoperative precise assessment of MV configuration may serve as a basis for selection of appropriate ring size and SMV-leg length.",
    keywords = "Animal models, Echocardiography, Mitral valve",
    author = "Satoshi Kainuma and Hitoshi Kasegawa and Shigeru Miyagawa and Hiroyuki Nishi and Hitoshi Yaku and Shuichiro Takanashi and Kazuhiro Hashimoto and Yukikatsu Okada and Satoshi Nakatani and Mitsuo Umezu and Takashi Daimon and Taichi Sakaguchi and Koichi Toda and Yoshiki Sawa",
    year = "2015",
    doi = "10.1253/circj.CJ-14-1113",
    language = "English",
    volume = "79",
    pages = "553--559",
    journal = "Circulation Journal",
    issn = "1346-9843",
    publisher = "Japanese Circulation Society",
    number = "3",

    }

    TY - JOUR

    T1 - In vivo assessment of novel stentless valve in the mitral position

    AU - Kainuma, Satoshi

    AU - Kasegawa, Hitoshi

    AU - Miyagawa, Shigeru

    AU - Nishi, Hiroyuki

    AU - Yaku, Hitoshi

    AU - Takanashi, Shuichiro

    AU - Hashimoto, Kazuhiro

    AU - Okada, Yukikatsu

    AU - Nakatani, Satoshi

    AU - Umezu, Mitsuo

    AU - Daimon, Takashi

    AU - Sakaguchi, Taichi

    AU - Toda, Koichi

    AU - Sawa, Yoshiki

    PY - 2015

    Y1 - 2015

    N2 - Background: We conducted in vivo examinations of a newly designed stentless mitral valve (SMV), formed by suturing 2 leaflets with the “legs” serving as chorda tendinea, made from bovine pericardium, to a flexible ring. Methods and Results: Seven pigs underwent implantation of the SMV constructed with a 23-mm (n=5) or 25-mm (n=2) Duran ring. Baseline echocardiography examinations were used to evaluate the annular anteroposterior diameter, and distance between the mitral annulus (MA) and papillary muscles (PMs) to determine SMV-leg length. After removing the native valve, the SMV-legs were fixed to the anterior and posterior PMs, followed by fixation of the ring to the native MA. Immediately after surgery, all animals presented none or trivial mitral regurgitation, with mean and peak trans-SMV pressure gradient values of 1.9±0.8 and 6.0±3.1 mmHg, respectively. The mean length of the SMV-leg was 19.4±3.9 mm, which correlated with the distance between anterior and posterior MA-PM (r=0.96 and 0.94, respectively, P<0.01 for both). The discrepancy between the anteroposterior diameter of the ring (outside diameter) and that of the native valve was 1.0±2.9 mm, which correlated with the trans-SMV pressure gradient (r=0.81, P=0.025). Conclusions: In our preliminary study, the SMV demonstrated excellent diastolic inflow dynamics and closing function in vivo. Preoperative precise assessment of MV configuration may serve as a basis for selection of appropriate ring size and SMV-leg length.

    AB - Background: We conducted in vivo examinations of a newly designed stentless mitral valve (SMV), formed by suturing 2 leaflets with the “legs” serving as chorda tendinea, made from bovine pericardium, to a flexible ring. Methods and Results: Seven pigs underwent implantation of the SMV constructed with a 23-mm (n=5) or 25-mm (n=2) Duran ring. Baseline echocardiography examinations were used to evaluate the annular anteroposterior diameter, and distance between the mitral annulus (MA) and papillary muscles (PMs) to determine SMV-leg length. After removing the native valve, the SMV-legs were fixed to the anterior and posterior PMs, followed by fixation of the ring to the native MA. Immediately after surgery, all animals presented none or trivial mitral regurgitation, with mean and peak trans-SMV pressure gradient values of 1.9±0.8 and 6.0±3.1 mmHg, respectively. The mean length of the SMV-leg was 19.4±3.9 mm, which correlated with the distance between anterior and posterior MA-PM (r=0.96 and 0.94, respectively, P<0.01 for both). The discrepancy between the anteroposterior diameter of the ring (outside diameter) and that of the native valve was 1.0±2.9 mm, which correlated with the trans-SMV pressure gradient (r=0.81, P=0.025). Conclusions: In our preliminary study, the SMV demonstrated excellent diastolic inflow dynamics and closing function in vivo. Preoperative precise assessment of MV configuration may serve as a basis for selection of appropriate ring size and SMV-leg length.

    KW - Animal models

    KW - Echocardiography

    KW - Mitral valve

    UR - http://www.scopus.com/inward/record.url?scp=84923516300&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84923516300&partnerID=8YFLogxK

    U2 - 10.1253/circj.CJ-14-1113

    DO - 10.1253/circj.CJ-14-1113

    M3 - Article

    C2 - 25746539

    AN - SCOPUS:84923516300

    VL - 79

    SP - 553

    EP - 559

    JO - Circulation Journal

    JF - Circulation Journal

    SN - 1346-9843

    IS - 3

    ER -