In vivo assessment of novel stentless valve in the mitral position

Satoshi Kainuma, Hitoshi Kasegawa, Shigeru Miyagawa, Hiroyuki Nishi, Hitoshi Yaku, Shuichiro Takanashi, Kazuhiro Hashimoto, Yukikatsu Okada, Satoshi Nakatani, Mitsuo Umezu, Takashi Daimon, Taichi Sakaguchi, Koichi Toda, Yoshiki Sawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: We conducted in vivo examinations of a newly designed stentless mitral valve (SMV), formed by suturing 2 leaflets with the “legs” serving as chorda tendinea, made from bovine pericardium, to a flexible ring. Methods and Results: Seven pigs underwent implantation of the SMV constructed with a 23-mm (n=5) or 25-mm (n=2) Duran ring. Baseline echocardiography examinations were used to evaluate the annular anteroposterior diameter, and distance between the mitral annulus (MA) and papillary muscles (PMs) to determine SMV-leg length. After removing the native valve, the SMV-legs were fixed to the anterior and posterior PMs, followed by fixation of the ring to the native MA. Immediately after surgery, all animals presented none or trivial mitral regurgitation, with mean and peak trans-SMV pressure gradient values of 1.9±0.8 and 6.0±3.1 mmHg, respectively. The mean length of the SMV-leg was 19.4±3.9 mm, which correlated with the distance between anterior and posterior MA-PM (r=0.96 and 0.94, respectively, P<0.01 for both). The discrepancy between the anteroposterior diameter of the ring (outside diameter) and that of the native valve was 1.0±2.9 mm, which correlated with the trans-SMV pressure gradient (r=0.81, P=0.025). Conclusions: In our preliminary study, the SMV demonstrated excellent diastolic inflow dynamics and closing function in vivo. Preoperative precise assessment of MV configuration may serve as a basis for selection of appropriate ring size and SMV-leg length.

Original languageEnglish
Pages (from-to)553-559
Number of pages7
JournalCirculation Journal
Volume79
Issue number3
DOIs
Publication statusPublished - 2015 Jan 1

Keywords

  • Animal models
  • Echocardiography
  • Mitral valve

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Kainuma, S., Kasegawa, H., Miyagawa, S., Nishi, H., Yaku, H., Takanashi, S., Hashimoto, K., Okada, Y., Nakatani, S., Umezu, M., Daimon, T., Sakaguchi, T., Toda, K., & Sawa, Y. (2015). In vivo assessment of novel stentless valve in the mitral position. Circulation Journal, 79(3), 553-559. https://doi.org/10.1253/circj.CJ-14-1113