In vivo deployment of mechanically adaptive nanocomposites for intracortical microelectrodes

J. P. Harris, A. E. Hess, S. J. Rowan, C. Weder, C. A. Zorman, D. J. Tyler, J. R. Capadona

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

We recently introduced a series of stimuli-responsive, mechanically adaptive polymer nanocomposites. Here, we report the first application of these bio-inspired materials as substrates for intracortical microelectrodes. Our hypothesis is that the ideal electrode should be initially stiff to facilitate minimal trauma during insertion into the cortex, yet become mechanically compliant to match the stiffness of the brain tissue and minimize forces exerted on the tissue, attenuating inflammation. Microprobes created from mechanically reinforced nanocomposites demonstrated a significant advantage compared to model microprobes composed of neat polymer only. The nanocomposite microprobes exhibit a higher storage modulus (E′ = ∼5 GPa) than the neat polymer microprobes (E′ = ∼2 GPa) and can sustain higher loads (∼12 mN), facilitating penetration through the pia mater and insertion into the cerebral cortex of a rat. In contrast, the neat polymer microprobes mechanically failed under lower loads (∼7 mN) before they were capable of insertion into cortical tissue. Further, we demonstrated the material's ability to morph while in the rat cortex to more closely match the mechanical properties of the cortical tissue. Nanocomposite microprobes that were implanted into the rat cortex for up to eight weeks demonstrated increased cell density at the microelectrode-tissue interface and a lack of tissue necrosis or excessive gliosis. This body of work introduces our nanocomposite-based microprobes as adaptive substrates for intracortical microelectrodes and potentially for other biomedical applications.

Original languageEnglish
Article number046010
JournalJournal of Neural Engineering
Volume8
Issue number4
DOIs
Publication statusPublished - 2011 Aug
Externally publishedYes

Fingerprint

Nanocomposites
Microelectrodes
Tissue
Polymers
Rats
Pia Mater
Gliosis
Substrates
Cerebral Cortex
Brain
Electrodes
Necrosis
Cell Count
Elastic moduli
Stiffness
Inflammation
Mechanical properties
Wounds and Injuries

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cellular and Molecular Neuroscience

Cite this

Harris, J. P., Hess, A. E., Rowan, S. J., Weder, C., Zorman, C. A., Tyler, D. J., & Capadona, J. R. (2011). In vivo deployment of mechanically adaptive nanocomposites for intracortical microelectrodes. Journal of Neural Engineering, 8(4), [046010]. https://doi.org/10.1088/1741-2560/8/4/046010

In vivo deployment of mechanically adaptive nanocomposites for intracortical microelectrodes. / Harris, J. P.; Hess, A. E.; Rowan, S. J.; Weder, C.; Zorman, C. A.; Tyler, D. J.; Capadona, J. R.

In: Journal of Neural Engineering, Vol. 8, No. 4, 046010, 08.2011.

Research output: Contribution to journalArticle

Harris, JP, Hess, AE, Rowan, SJ, Weder, C, Zorman, CA, Tyler, DJ & Capadona, JR 2011, 'In vivo deployment of mechanically adaptive nanocomposites for intracortical microelectrodes', Journal of Neural Engineering, vol. 8, no. 4, 046010. https://doi.org/10.1088/1741-2560/8/4/046010
Harris, J. P. ; Hess, A. E. ; Rowan, S. J. ; Weder, C. ; Zorman, C. A. ; Tyler, D. J. ; Capadona, J. R. / In vivo deployment of mechanically adaptive nanocomposites for intracortical microelectrodes. In: Journal of Neural Engineering. 2011 ; Vol. 8, No. 4.
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