In vivo evaluation of a MPC polymer coated continuous flow left ventricular assist system

Shin'ichiro Kihara, Kenji Yamazaki, Kenneth N. Litwak, Philip Litwak, Marina V. Kameneva, Hiroyuki Ushiyama, Toshimasa Tokuno, David C. Borzelleca, Mitsuo Umezu, Jun Tomioka, Osamu Tagusari, Takehide Akimoto, Hitoshi Koyanagi, Hiromi Kurosawa, Robert L. Kormos, Bartley P. Griffith

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    59 Citations (Scopus)

    Abstract

    The aim of this study was the evaluation of the thrombogenicity and the biocompatibility of the SunMedical EVAHEART left ventricular assist system (LVAS) coated with 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer compared to a diamond-like carbon (DLC) coating. Four calves were implanted with the MPC polymer-coated LVAS. Eight calves were implanted with DLC coated LVAS. The thrombogenicity and biocompatibility of the pumps were evaluated. At explant, 60.0 ± 37.2% (5-85%) of the pump surface area was still coated with MPC polymer after the duration of 45.0 ± 32.0 days. In 1 out of 4 MPC and 2 out of 8 DLC coated pumps, there was a very small amount of thrombus around the seal ring; otherwise the blood contacting surfaces were free of thrombus. Major organs were normal except for a few lesions in kidneys from both groups. The MPC polymer coated EVAHEART LVAS seems to have low thrombogenicity and high biocompatibility similar to the DLC coated system. The current study demonstrated that the MPC polymer coating shows great promise for being used as an antithrombogenic substrate for the LVAS due to its ease of application, significant cost benefit, and reduction in anticoagulation therapy in acute postoperative period.

    Original languageEnglish
    Pages (from-to)188-192
    Number of pages5
    JournalArtificial Organs
    Volume27
    Issue number2
    DOIs
    Publication statusPublished - 2003 Feb 1

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    Keywords

    • 2-methacryloyloxyethyl phosphorylcholine
    • Biocompatibility
    • Diamond-like carbon
    • Left ventricular assist device
    • Rotary blood pump
    • Thrombogenicity

    ASJC Scopus subject areas

    • Biophysics

    Cite this

    Kihara, S., Yamazaki, K., Litwak, K. N., Litwak, P., Kameneva, M. V., Ushiyama, H., Tokuno, T., Borzelleca, D. C., Umezu, M., Tomioka, J., Tagusari, O., Akimoto, T., Koyanagi, H., Kurosawa, H., Kormos, R. L., & Griffith, B. P. (2003). In vivo evaluation of a MPC polymer coated continuous flow left ventricular assist system. Artificial Organs, 27(2), 188-192. https://doi.org/10.1046/j.1525-1594.2003.t01-2-06993.x