In Vivo Gold Complex Catalysis within Live Mice

Kazuki Tsubokura, Kenward K H Vong, Ambara R. Pradipta, Akihiro Ogura, Sayaka Urano, Tsuyoshi Tahara, Satoshi Nozaki, Hirotaka Onoe, Youichi Nakao, Regina Sibgatullina, Almira Kurbangalieva, Yasuyoshi Watanabe, Katsunori Tanaka

    Research output: Contribution to journalArticle

    46 Citations (Scopus)

    Abstract

    Metal complex catalysis within biological systems is largely limited to cell and bacterial systems. In this work, a glycoalbumin–AuIII complex was designed and developed that enables organ-specific, localized propargyl ester amidation with nearby proteins within live mice. The targeted reactivity can be imaged through the use of Cy7.5- and TAMRA-linked propargyl ester based fluorescent probes. This targeting system could enable the exploitation of other metal catalysis strategies for biomedical and clinical applications.

    Original languageEnglish
    Pages (from-to)3579-3584
    Number of pages6
    JournalAngewandte Chemie - International Edition
    Volume56
    Issue number13
    DOIs
    Publication statusPublished - 2017 Mar 20

    Keywords

    • amide bond formation
    • fluorescent labeling
    • glycoalbumin
    • gold catalysis

    ASJC Scopus subject areas

    • Catalysis
    • Chemistry(all)

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  • Cite this

    Tsubokura, K., Vong, K. K. H., Pradipta, A. R., Ogura, A., Urano, S., Tahara, T., Nozaki, S., Onoe, H., Nakao, Y., Sibgatullina, R., Kurbangalieva, A., Watanabe, Y., & Tanaka, K. (2017). In Vivo Gold Complex Catalysis within Live Mice. Angewandte Chemie - International Edition, 56(13), 3579-3584. https://doi.org/10.1002/anie.201610273