In Vivo Gold Complex Catalysis within Live Mice

Kazuki Tsubokura, Kenward K H Vong, Ambara R. Pradipta, Akihiro Ogura, Sayaka Urano, Tsuyoshi Tahara, Satoshi Nozaki, Hirotaka Onoe, Youichi Nakao, Regina Sibgatullina, Almira Kurbangalieva, Yasuyoshi Watanabe, Katsunori Tanaka

    Research output: Contribution to journalArticle

    34 Citations (Scopus)

    Abstract

    Metal complex catalysis within biological systems is largely limited to cell and bacterial systems. In this work, a glycoalbumin–AuIII complex was designed and developed that enables organ-specific, localized propargyl ester amidation with nearby proteins within live mice. The targeted reactivity can be imaged through the use of Cy7.5- and TAMRA-linked propargyl ester based fluorescent probes. This targeting system could enable the exploitation of other metal catalysis strategies for biomedical and clinical applications.

    Original languageEnglish
    Pages (from-to)3579-3584
    Number of pages6
    JournalAngewandte Chemie - International Edition
    Volume56
    Issue number13
    DOIs
    Publication statusPublished - 2017 Mar 20

    Fingerprint

    Gold
    Catalysis
    Esters
    Coordination Complexes
    Biological systems
    Metal complexes
    Fluorescent Dyes
    Metals
    Proteins

    Keywords

    • amide bond formation
    • fluorescent labeling
    • glycoalbumin
    • gold catalysis

    ASJC Scopus subject areas

    • Catalysis
    • Chemistry(all)

    Cite this

    Tsubokura, K., Vong, K. K. H., Pradipta, A. R., Ogura, A., Urano, S., Tahara, T., ... Tanaka, K. (2017). In Vivo Gold Complex Catalysis within Live Mice. Angewandte Chemie - International Edition, 56(13), 3579-3584. https://doi.org/10.1002/anie.201610273

    In Vivo Gold Complex Catalysis within Live Mice. / Tsubokura, Kazuki; Vong, Kenward K H; Pradipta, Ambara R.; Ogura, Akihiro; Urano, Sayaka; Tahara, Tsuyoshi; Nozaki, Satoshi; Onoe, Hirotaka; Nakao, Youichi; Sibgatullina, Regina; Kurbangalieva, Almira; Watanabe, Yasuyoshi; Tanaka, Katsunori.

    In: Angewandte Chemie - International Edition, Vol. 56, No. 13, 20.03.2017, p. 3579-3584.

    Research output: Contribution to journalArticle

    Tsubokura, K, Vong, KKH, Pradipta, AR, Ogura, A, Urano, S, Tahara, T, Nozaki, S, Onoe, H, Nakao, Y, Sibgatullina, R, Kurbangalieva, A, Watanabe, Y & Tanaka, K 2017, 'In Vivo Gold Complex Catalysis within Live Mice', Angewandte Chemie - International Edition, vol. 56, no. 13, pp. 3579-3584. https://doi.org/10.1002/anie.201610273
    Tsubokura K, Vong KKH, Pradipta AR, Ogura A, Urano S, Tahara T et al. In Vivo Gold Complex Catalysis within Live Mice. Angewandte Chemie - International Edition. 2017 Mar 20;56(13):3579-3584. https://doi.org/10.1002/anie.201610273
    Tsubokura, Kazuki ; Vong, Kenward K H ; Pradipta, Ambara R. ; Ogura, Akihiro ; Urano, Sayaka ; Tahara, Tsuyoshi ; Nozaki, Satoshi ; Onoe, Hirotaka ; Nakao, Youichi ; Sibgatullina, Regina ; Kurbangalieva, Almira ; Watanabe, Yasuyoshi ; Tanaka, Katsunori. / In Vivo Gold Complex Catalysis within Live Mice. In: Angewandte Chemie - International Edition. 2017 ; Vol. 56, No. 13. pp. 3579-3584.
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