In vivo O2-transport of totally synthetic artificial red cell (lipid-heme-microsphere)

T. Komatsu, Y. Muramatsu, Hiroyuki Nishide, E. Tuchida, T. Kakizaki, K. Kobayashi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In vivo O2-transporting ability of totally synthetic artificial red cell (lipid-heme-microsphere) is described. O2-Binding affinity of the lipid-heme-microsphere (P( 1/2 )(O2): ca. 40 Torr at 37°C was slightly lower than that of red cell (human blood) and its O2-association and -dissociation rate constants were larger than those of hemoglobin. O2-Solubility of the lipid-heme-microsphere dispersion was estimated. Highly O2-dissolved aqueous solution can be prepared by the prescription of the lipid-heme-microsphere. The totally synthetic artificial red cell suspension was intravenously injected into hemorrhagic beagles (8 kg). Circulation life-time of each constituent of this system and O2-consumption by the lipid-heme was determined. These results suggest that the lipid-heme-microsphere has an ability to act as an efficient O2-carrier in blood stream.

Original languageEnglish
Pages (from-to)849-853
Number of pages5
JournalJapanese Journal of Artificial Organs
Volume23
Issue number3
Publication statusPublished - 1994

Keywords

  • artificial red cell
  • blood substitute
  • exchange transfusion
  • heme
  • lipid microsphere
  • oxygen transport

ASJC Scopus subject areas

  • Biophysics

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    Komatsu, T., Muramatsu, Y., Nishide, H., Tuchida, E., Kakizaki, T., & Kobayashi, K. (1994). In vivo O2-transport of totally synthetic artificial red cell (lipid-heme-microsphere). Japanese Journal of Artificial Organs, 23(3), 849-853.