In vivo O2-transport of totally synthetic artificial red cell (lipid-heme-microsphere)

T. Komatsu, Y. Muramatsu, Hiroyuki Nishide, E. Tuchida, T. Kakizaki, K. Kobayashi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In vivo O2-transporting ability of totally synthetic artificial red cell (lipid-heme-microsphere) is described. O2-Binding affinity of the lipid-heme-microsphere (P( 1/2 )(O2): ca. 40 Torr at 37°C was slightly lower than that of red cell (human blood) and its O2-association and -dissociation rate constants were larger than those of hemoglobin. O2-Solubility of the lipid-heme-microsphere dispersion was estimated. Highly O2-dissolved aqueous solution can be prepared by the prescription of the lipid-heme-microsphere. The totally synthetic artificial red cell suspension was intravenously injected into hemorrhagic beagles (8 kg). Circulation life-time of each constituent of this system and O2-consumption by the lipid-heme was determined. These results suggest that the lipid-heme-microsphere has an ability to act as an efficient O2-carrier in blood stream.

Original languageEnglish
Pages (from-to)849-853
Number of pages5
JournalJapanese Journal of Artificial Organs
Volume23
Issue number3
Publication statusPublished - 1994

Fingerprint

Artificial Cells
Heme
Microspheres
Lipids
Solubility
Prescriptions
Suspensions
Hemoglobins
Erythrocytes

Keywords

  • artificial red cell
  • blood substitute
  • exchange transfusion
  • heme
  • lipid microsphere
  • oxygen transport

ASJC Scopus subject areas

  • Biophysics

Cite this

Komatsu, T., Muramatsu, Y., Nishide, H., Tuchida, E., Kakizaki, T., & Kobayashi, K. (1994). In vivo O2-transport of totally synthetic artificial red cell (lipid-heme-microsphere). Japanese Journal of Artificial Organs, 23(3), 849-853.

In vivo O2-transport of totally synthetic artificial red cell (lipid-heme-microsphere). / Komatsu, T.; Muramatsu, Y.; Nishide, Hiroyuki; Tuchida, E.; Kakizaki, T.; Kobayashi, K.

In: Japanese Journal of Artificial Organs, Vol. 23, No. 3, 1994, p. 849-853.

Research output: Contribution to journalArticle

Komatsu, T, Muramatsu, Y, Nishide, H, Tuchida, E, Kakizaki, T & Kobayashi, K 1994, 'In vivo O2-transport of totally synthetic artificial red cell (lipid-heme-microsphere)', Japanese Journal of Artificial Organs, vol. 23, no. 3, pp. 849-853.
Komatsu, T. ; Muramatsu, Y. ; Nishide, Hiroyuki ; Tuchida, E. ; Kakizaki, T. ; Kobayashi, K. / In vivo O2-transport of totally synthetic artificial red cell (lipid-heme-microsphere). In: Japanese Journal of Artificial Organs. 1994 ; Vol. 23, No. 3. pp. 849-853.
@article{03817c9507614810a6afe4d17ca8d4fd,
title = "In vivo O2-transport of totally synthetic artificial red cell (lipid-heme-microsphere)",
abstract = "In vivo O2-transporting ability of totally synthetic artificial red cell (lipid-heme-microsphere) is described. O2-Binding affinity of the lipid-heme-microsphere (P( 1/2 )(O2): ca. 40 Torr at 37°C was slightly lower than that of red cell (human blood) and its O2-association and -dissociation rate constants were larger than those of hemoglobin. O2-Solubility of the lipid-heme-microsphere dispersion was estimated. Highly O2-dissolved aqueous solution can be prepared by the prescription of the lipid-heme-microsphere. The totally synthetic artificial red cell suspension was intravenously injected into hemorrhagic beagles (8 kg). Circulation life-time of each constituent of this system and O2-consumption by the lipid-heme was determined. These results suggest that the lipid-heme-microsphere has an ability to act as an efficient O2-carrier in blood stream.",
keywords = "artificial red cell, blood substitute, exchange transfusion, heme, lipid microsphere, oxygen transport",
author = "T. Komatsu and Y. Muramatsu and Hiroyuki Nishide and E. Tuchida and T. Kakizaki and K. Kobayashi",
year = "1994",
language = "English",
volume = "23",
pages = "849--853",
journal = "Japanese Journal of Artificial Organs",
issn = "0300-0818",
publisher = "Japanese Society for Artificial Organs and Tissues",
number = "3",

}

TY - JOUR

T1 - In vivo O2-transport of totally synthetic artificial red cell (lipid-heme-microsphere)

AU - Komatsu, T.

AU - Muramatsu, Y.

AU - Nishide, Hiroyuki

AU - Tuchida, E.

AU - Kakizaki, T.

AU - Kobayashi, K.

PY - 1994

Y1 - 1994

N2 - In vivo O2-transporting ability of totally synthetic artificial red cell (lipid-heme-microsphere) is described. O2-Binding affinity of the lipid-heme-microsphere (P( 1/2 )(O2): ca. 40 Torr at 37°C was slightly lower than that of red cell (human blood) and its O2-association and -dissociation rate constants were larger than those of hemoglobin. O2-Solubility of the lipid-heme-microsphere dispersion was estimated. Highly O2-dissolved aqueous solution can be prepared by the prescription of the lipid-heme-microsphere. The totally synthetic artificial red cell suspension was intravenously injected into hemorrhagic beagles (8 kg). Circulation life-time of each constituent of this system and O2-consumption by the lipid-heme was determined. These results suggest that the lipid-heme-microsphere has an ability to act as an efficient O2-carrier in blood stream.

AB - In vivo O2-transporting ability of totally synthetic artificial red cell (lipid-heme-microsphere) is described. O2-Binding affinity of the lipid-heme-microsphere (P( 1/2 )(O2): ca. 40 Torr at 37°C was slightly lower than that of red cell (human blood) and its O2-association and -dissociation rate constants were larger than those of hemoglobin. O2-Solubility of the lipid-heme-microsphere dispersion was estimated. Highly O2-dissolved aqueous solution can be prepared by the prescription of the lipid-heme-microsphere. The totally synthetic artificial red cell suspension was intravenously injected into hemorrhagic beagles (8 kg). Circulation life-time of each constituent of this system and O2-consumption by the lipid-heme was determined. These results suggest that the lipid-heme-microsphere has an ability to act as an efficient O2-carrier in blood stream.

KW - artificial red cell

KW - blood substitute

KW - exchange transfusion

KW - heme

KW - lipid microsphere

KW - oxygen transport

UR - http://www.scopus.com/inward/record.url?scp=0028364134&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028364134&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0028364134

VL - 23

SP - 849

EP - 853

JO - Japanese Journal of Artificial Organs

JF - Japanese Journal of Artificial Organs

SN - 0300-0818

IS - 3

ER -