In vivo studies on methemoglobin formation by sodium nitrite

Kazuhiko Imaizumi; Itiro Tyuma; Kiyohiro Imai; Hiroaki Kosaka; Yoshihiro Ueda

doi:10.1007/BF01274129

In vivo studies on methemoglobin formation by sodium nitrite

Kazuhiko Imaizumi^*, Itiro Tyuma, Kiyohiro Imai, Hiroaki Kosaka, Yoshihiro Ueda

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

The oral LD5o of NaNO₂ for rats was found to be 0.15 g per kg body weight. The methemoglobin level increased to 45-80%, 1 h after the administration of the LD5o dose and returned to the normal level after 24 h. The dose-maximum methemoglobin concentration curve was found to be Sshaped. Formation of nitrosyl hemoglobin preceded that of methemoglobin, its maximum concentration being a quarter of that of the latter derivative. In rats receiving 0.5% NaNO₂ as drinking water, the concentration of methemoglobin showed a characteristic daily change (4 to 88%) due to the circadian rhythm of the animal in drinking. After 6 months, slight nitrosyl hemoglobin production, Heinz body formation, anisocytosis, and hypohemoglobinemia were observed.

Original language	English
Pages (from-to)	97-104
Number of pages	8
Journal	International Archives of Occupational and Environmental Health
Volume	45
Issue number	2
DOIs	https://doi.org/10.1007/BF01274129
Publication status	Published - 1980 Jun
Externally published	Yes

Keywords

Methemoglobin
Nitrite
Nitrosyl hemoglobin

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF01274129

Cite this

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title = "In vivo studies on methemoglobin formation by sodium nitrite",

abstract = "The oral LD5o of NaNO2 for rats was found to be 0.15 g per kg body weight. The methemoglobin level increased to 45-80%, 1 h after the administration of the LD5o dose and returned to the normal level after 24 h. The dose-maximum methemoglobin concentration curve was found to be Sshaped. Formation of nitrosyl hemoglobin preceded that of methemoglobin, its maximum concentration being a quarter of that of the latter derivative. In rats receiving 0.5% NaNO2 as drinking water, the concentration of methemoglobin showed a characteristic daily change (4 to 88%) due to the circadian rhythm of the animal in drinking. After 6 months, slight nitrosyl hemoglobin production, Heinz body formation, anisocytosis, and hypohemoglobinemia were observed.",

keywords = "Methemoglobin, Nitrite, Nitrosyl hemoglobin",

author = "Kazuhiko Imaizumi and Itiro Tyuma and Kiyohiro Imai and Hiroaki Kosaka and Yoshihiro Ueda",

year = "1980",

month = jun,

doi = "10.1007/BF01274129",

language = "English",

volume = "45",

pages = "97--104",

journal = "International Archives of Occupational and Environmental Health",

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TY - JOUR

T1 - In vivo studies on methemoglobin formation by sodium nitrite

AU - Imaizumi, Kazuhiko

AU - Tyuma, Itiro

AU - Imai, Kiyohiro

AU - Kosaka, Hiroaki

AU - Ueda, Yoshihiro

PY - 1980/6

Y1 - 1980/6

N2 - The oral LD5o of NaNO2 for rats was found to be 0.15 g per kg body weight. The methemoglobin level increased to 45-80%, 1 h after the administration of the LD5o dose and returned to the normal level after 24 h. The dose-maximum methemoglobin concentration curve was found to be Sshaped. Formation of nitrosyl hemoglobin preceded that of methemoglobin, its maximum concentration being a quarter of that of the latter derivative. In rats receiving 0.5% NaNO2 as drinking water, the concentration of methemoglobin showed a characteristic daily change (4 to 88%) due to the circadian rhythm of the animal in drinking. After 6 months, slight nitrosyl hemoglobin production, Heinz body formation, anisocytosis, and hypohemoglobinemia were observed.

AB - The oral LD5o of NaNO2 for rats was found to be 0.15 g per kg body weight. The methemoglobin level increased to 45-80%, 1 h after the administration of the LD5o dose and returned to the normal level after 24 h. The dose-maximum methemoglobin concentration curve was found to be Sshaped. Formation of nitrosyl hemoglobin preceded that of methemoglobin, its maximum concentration being a quarter of that of the latter derivative. In rats receiving 0.5% NaNO2 as drinking water, the concentration of methemoglobin showed a characteristic daily change (4 to 88%) due to the circadian rhythm of the animal in drinking. After 6 months, slight nitrosyl hemoglobin production, Heinz body formation, anisocytosis, and hypohemoglobinemia were observed.

KW - Methemoglobin

KW - Nitrite

KW - Nitrosyl hemoglobin

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In vivo studies on methemoglobin formation by sodium nitrite

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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