In vivo studies on methemoglobin formation by sodium nitrite

Kazuhiko Imaizumi, Itiro Tyuma, Kiyohiro Imai, Hiroaki Kosaka, Yoshihiro Ueda

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The oral LD5o of NaNO2 for rats was found to be 0.15 g per kg body weight. The methemoglobin level increased to 45-80%, 1 h after the administration of the LD5o dose and returned to the normal level after 24 h. The dose-maximum methemoglobin concentration curve was found to be Sshaped. Formation of nitrosyl hemoglobin preceded that of methemoglobin, its maximum concentration being a quarter of that of the latter derivative. In rats receiving 0.5% NaNO2 as drinking water, the concentration of methemoglobin showed a characteristic daily change (4 to 88%) due to the circadian rhythm of the animal in drinking. After 6 months, slight nitrosyl hemoglobin production, Heinz body formation, anisocytosis, and hypohemoglobinemia were observed.

Original languageEnglish
Pages (from-to)97-104
Number of pages8
JournalInternational Archives of Occupational and Environmental Health
Volume45
Issue number2
DOIs
Publication statusPublished - 1980 Jun
Externally publishedYes

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Sodium Nitrite
Methemoglobin
Heinz Bodies
Circadian Rhythm
Drinking Water
Drinking
Body Weight
nitrosyl hemoglobin

Keywords

  • Methemoglobin
  • Nitrite
  • Nitrosyl hemoglobin

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

In vivo studies on methemoglobin formation by sodium nitrite. / Imaizumi, Kazuhiko; Tyuma, Itiro; Imai, Kiyohiro; Kosaka, Hiroaki; Ueda, Yoshihiro.

In: International Archives of Occupational and Environmental Health, Vol. 45, No. 2, 06.1980, p. 97-104.

Research output: Contribution to journalArticle

Imaizumi, Kazuhiko ; Tyuma, Itiro ; Imai, Kiyohiro ; Kosaka, Hiroaki ; Ueda, Yoshihiro. / In vivo studies on methemoglobin formation by sodium nitrite. In: International Archives of Occupational and Environmental Health. 1980 ; Vol. 45, No. 2. pp. 97-104.
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