In vivo ultrahigh-resolution ophthalmic optical coherence tomography using Gaussian-shaped supercontinuum

Masahiro Nishiura, Toshihiro Kobayashi, Muneyuki Adachi, Jun Nakanishi, Tokio Ueno, Yasuki Ito, Norihiko Nishizawa

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

We have demonstrated the in vivo ultrahigh-resolution optical coherence tomography (OCT) imaging of the human eye using a Gaussian-shaped supercontinuum source. Using an ultrashort-pulse Ti:sapphire laser and a polarization- maintaining single-mode fiber, a linearly polarized, high-power, low-noise, Gaussian-shaped supercontinuum is generated in the wavelength region from 700 to 950 nm. For ophthalmic imaging, a wideband Gaussian-shaped supercontinuum with a bandwidth of 140nm is generated at a center wavelength of 830 nm. The observed axial resolutions are 2.9 μm in air and 2.1μm in tissue. The generated supercontinuum is combined with a modified ophthalmic OCT system, and sidelobe-free ultrahigh-resolution OCT images of the human retina and cornea are obtained.

Original languageEnglish
Article number012701
JournalJapanese journal of applied physics
Volume49
Issue number1 Part 1
DOIs
Publication statusPublished - 2010 Apr 19
Externally publishedYes

Fingerprint

Optical tomography
tomography
Polarization-maintaining fiber
Imaging techniques
Wavelength
cornea
sidelobes
retina
Single mode fibers
Ultrashort pulses
Sapphire
wavelengths
low noise
sapphire
Tissue
broadband
bandwidth
Bandwidth
fibers
Lasers

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

In vivo ultrahigh-resolution ophthalmic optical coherence tomography using Gaussian-shaped supercontinuum. / Nishiura, Masahiro; Kobayashi, Toshihiro; Adachi, Muneyuki; Nakanishi, Jun; Ueno, Tokio; Ito, Yasuki; Nishizawa, Norihiko.

In: Japanese journal of applied physics, Vol. 49, No. 1 Part 1, 012701, 19.04.2010.

Research output: Contribution to journalArticle

Nishiura, Masahiro ; Kobayashi, Toshihiro ; Adachi, Muneyuki ; Nakanishi, Jun ; Ueno, Tokio ; Ito, Yasuki ; Nishizawa, Norihiko. / In vivo ultrahigh-resolution ophthalmic optical coherence tomography using Gaussian-shaped supercontinuum. In: Japanese journal of applied physics. 2010 ; Vol. 49, No. 1 Part 1.
@article{4909d996a7a744b68d63a44114745eae,
title = "In vivo ultrahigh-resolution ophthalmic optical coherence tomography using Gaussian-shaped supercontinuum",
abstract = "We have demonstrated the in vivo ultrahigh-resolution optical coherence tomography (OCT) imaging of the human eye using a Gaussian-shaped supercontinuum source. Using an ultrashort-pulse Ti:sapphire laser and a polarization- maintaining single-mode fiber, a linearly polarized, high-power, low-noise, Gaussian-shaped supercontinuum is generated in the wavelength region from 700 to 950 nm. For ophthalmic imaging, a wideband Gaussian-shaped supercontinuum with a bandwidth of 140nm is generated at a center wavelength of 830 nm. The observed axial resolutions are 2.9 μm in air and 2.1μm in tissue. The generated supercontinuum is combined with a modified ophthalmic OCT system, and sidelobe-free ultrahigh-resolution OCT images of the human retina and cornea are obtained.",
author = "Masahiro Nishiura and Toshihiro Kobayashi and Muneyuki Adachi and Jun Nakanishi and Tokio Ueno and Yasuki Ito and Norihiko Nishizawa",
year = "2010",
month = "4",
day = "19",
doi = "10.1143/JJAP.49.012701",
language = "English",
volume = "49",
journal = "Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes",
issn = "0021-4922",
publisher = "Japan Society of Applied Physics",
number = "1 Part 1",

}

TY - JOUR

T1 - In vivo ultrahigh-resolution ophthalmic optical coherence tomography using Gaussian-shaped supercontinuum

AU - Nishiura, Masahiro

AU - Kobayashi, Toshihiro

AU - Adachi, Muneyuki

AU - Nakanishi, Jun

AU - Ueno, Tokio

AU - Ito, Yasuki

AU - Nishizawa, Norihiko

PY - 2010/4/19

Y1 - 2010/4/19

N2 - We have demonstrated the in vivo ultrahigh-resolution optical coherence tomography (OCT) imaging of the human eye using a Gaussian-shaped supercontinuum source. Using an ultrashort-pulse Ti:sapphire laser and a polarization- maintaining single-mode fiber, a linearly polarized, high-power, low-noise, Gaussian-shaped supercontinuum is generated in the wavelength region from 700 to 950 nm. For ophthalmic imaging, a wideband Gaussian-shaped supercontinuum with a bandwidth of 140nm is generated at a center wavelength of 830 nm. The observed axial resolutions are 2.9 μm in air and 2.1μm in tissue. The generated supercontinuum is combined with a modified ophthalmic OCT system, and sidelobe-free ultrahigh-resolution OCT images of the human retina and cornea are obtained.

AB - We have demonstrated the in vivo ultrahigh-resolution optical coherence tomography (OCT) imaging of the human eye using a Gaussian-shaped supercontinuum source. Using an ultrashort-pulse Ti:sapphire laser and a polarization- maintaining single-mode fiber, a linearly polarized, high-power, low-noise, Gaussian-shaped supercontinuum is generated in the wavelength region from 700 to 950 nm. For ophthalmic imaging, a wideband Gaussian-shaped supercontinuum with a bandwidth of 140nm is generated at a center wavelength of 830 nm. The observed axial resolutions are 2.9 μm in air and 2.1μm in tissue. The generated supercontinuum is combined with a modified ophthalmic OCT system, and sidelobe-free ultrahigh-resolution OCT images of the human retina and cornea are obtained.

UR - http://www.scopus.com/inward/record.url?scp=77950796236&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950796236&partnerID=8YFLogxK

U2 - 10.1143/JJAP.49.012701

DO - 10.1143/JJAP.49.012701

M3 - Article

VL - 49

JO - Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes

JF - Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes

SN - 0021-4922

IS - 1 Part 1

M1 - 012701

ER -