Increase in cyclic AMP concentration in a cerebral giant interneuron mimics part of a memory trace for conditioned taste aversion of the pond snail

Emi Otsuka, Miho Matsunaga, Ryuichi Okada, Miki Yamagishi, Akiko Okuta, Ken Lukowiak, Etsuro Ito

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Conditioned taste aversion (CTA) can be classically conditioned in the pond snail Lymnaea stagnalis and subsequently be consolidated into long-term memory (LTM). The neural trace that subserves CTA-LTM can be summarized as follows: A polysynaptic inhibitory postsyn-aptic potential recorded in the neuron 1 medial (N1M) cell in the conditioned snails as a result of activation of the cerebral giant cell (CGC) is larger and lasts longer than that in control snails. The N1M cell is ultimately activated by the CGC via the neuron 3 tonic (N3t) cell. That is, the inhibitory monosynaptic inputs from the N3t cell to the N1M cell are facilitated. The N1M and N3t cells are the members of feeding central pattern generator, whereas the CGC is a multimodal interneuron thought to play a key role in feeding behavior. Here we examined the involvement of a second messenger, cAMP, in the establishment of the memory trace. We injected cAMP into the CGC and monitored the potentials of the B3 motor neuron activated by the CGC. B3 activity is used as an index for the synaptic inputs from the N3t cell to the N1M cell. We found that the B3 potentials were transiently enlarged. Thus, when the cAMP concentration is increased in the CGC by taste aversion training, cAMP-induced changes may play a key role in the establishment of a memory trace in the N3t cell.

Original languageEnglish
Pages (from-to)161-166
Number of pages6
JournalBiophysics (Japan)
Volume9
DOIs
Publication statusPublished - 2013
Externally publishedYes

Fingerprint

Snails
Interneurons
Cyclic AMP
Neurons
Giant Cells
Long-Term Memory
Feeding Behavior
Central Pattern Generators
Lymnaea
Second Messenger Systems
Motor Neurons

Keywords

  • cAMP
  • Conditioned taste aversion
  • Feeding
  • Lymnaea
  • Memory trace

ASJC Scopus subject areas

  • Biophysics

Cite this

Increase in cyclic AMP concentration in a cerebral giant interneuron mimics part of a memory trace for conditioned taste aversion of the pond snail. / Otsuka, Emi; Matsunaga, Miho; Okada, Ryuichi; Yamagishi, Miki; Okuta, Akiko; Lukowiak, Ken; Ito, Etsuro.

In: Biophysics (Japan), Vol. 9, 2013, p. 161-166.

Research output: Contribution to journalArticle

Otsuka, Emi ; Matsunaga, Miho ; Okada, Ryuichi ; Yamagishi, Miki ; Okuta, Akiko ; Lukowiak, Ken ; Ito, Etsuro. / Increase in cyclic AMP concentration in a cerebral giant interneuron mimics part of a memory trace for conditioned taste aversion of the pond snail. In: Biophysics (Japan). 2013 ; Vol. 9. pp. 161-166.
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