Increased cell functionalities with patterned co-cultures utilizing dual thermo-responsive polymer grafted surfaces

Y. Tsuda, A. Kikuchi, A. Nakao, M. Yamato, Y. Sakurai, M. Umezu, T. Okano

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The impact of increased cell functionalities with patterned co-cultures was investigated by utilizing thermo-responsive hydrophilic property changes of poly(N-isopropylacrylamide) (PIPAAm). It was observed that regulating transition temperature of PIPAAm produce new culture for co-culture and in recovering co-cultured cell sheets. The cell functions were estimated by altering pattern sizes in the co-culture system. The results show that the stratification of co-cultured cell sheets leads to the creation of novel tissue constructs structurally similar to the native organs and tissues.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Pages246
Number of pages1
Publication statusPublished - 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: 2004 May 172004 May 21

Publication series

NameTransactions - 7th World Biomaterials Congress

Other

OtherTransactions - 7th World Biomaterials Congress
Country/TerritoryAustralia
CitySydney
Period04/5/1704/5/21

ASJC Scopus subject areas

  • Engineering(all)

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