Increased cerebral blood flow in the right frontal lobe area during sleep precedes self-awakening in humans

Sayaka Aritake, Shigekazu Higuchi, Hiroyuki Suzuki, Kenichi Kuriyama, Minori Enomoto, Takahiro Soshi, Shingo Kitamura, Akiko Hida, Kazuo Mishima

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Some people can subconsciously wake up naturally (self-awakening) at a desired/planned time without external time stimuli. However, the underlying mechanism regulating this ability remains to be elucidated. This study sought to examine the relationship between hemodynamic changes in oxyhemoglobin (oxy-Hb) level in the prefrontal cortex and sleep structures during sleep in subjects instructed to self-awaken.Results: Fifteen healthy right-handed male volunteers with regular sleep habits participated in a consecutive two-night crossover study. The subjects were instructed to wake up at a specified time (" request" condition) or instructed to sleep until the morning but forced to wake up at 03:00 without prior notice (" surprise" condition). Those who awoke within ± 30 min of the planned waking time were defined as those who succeeded in self-awakening (" success" group). Seven subjects succeeded in self-awakening and eight failed.No significant differences were observed in the amounts of sleep in each stage between conditions or between groups. On the " request" night, an increase in oxy-Hb level in the right prefrontal cortex and a decrease in δ power were observed in the " success" group around 30 min before self-awakening, whereas no such changes were observed in the " failure" group. On the " surprise" night, no significant changes were observed in oxy-Hb level or δ power in either group.Conclusions: These findings demonstrate a correlation between self-awakening and a pre-awakening increase in hemodynamic activation in the right prefrontal cortex, suggesting the structure's contribution to time estimation ability.

Original languageEnglish
Article number153
JournalBMC Neuroscience
Volume13
Issue number1
DOIs
Publication statusPublished - 2012 Dec 21
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Frontal Lobe
Sleep
Oxyhemoglobins
Prefrontal Cortex
Aptitude
Hemodynamics
Cross-Over Studies
Habits
Volunteers

Keywords

  • Cognitive science
  • Insomnia
  • Prefrontal cortex
  • Self-awakening
  • Sleep
  • Time estimation ability

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neuroscience(all)

Cite this

Aritake, S., Higuchi, S., Suzuki, H., Kuriyama, K., Enomoto, M., Soshi, T., ... Mishima, K. (2012). Increased cerebral blood flow in the right frontal lobe area during sleep precedes self-awakening in humans. BMC Neuroscience, 13(1), [153]. https://doi.org/10.1186/1471-2202-13-153

Increased cerebral blood flow in the right frontal lobe area during sleep precedes self-awakening in humans. / Aritake, Sayaka; Higuchi, Shigekazu; Suzuki, Hiroyuki; Kuriyama, Kenichi; Enomoto, Minori; Soshi, Takahiro; Kitamura, Shingo; Hida, Akiko; Mishima, Kazuo.

In: BMC Neuroscience, Vol. 13, No. 1, 153, 21.12.2012.

Research output: Contribution to journalArticle

Aritake, S, Higuchi, S, Suzuki, H, Kuriyama, K, Enomoto, M, Soshi, T, Kitamura, S, Hida, A & Mishima, K 2012, 'Increased cerebral blood flow in the right frontal lobe area during sleep precedes self-awakening in humans', BMC Neuroscience, vol. 13, no. 1, 153. https://doi.org/10.1186/1471-2202-13-153
Aritake, Sayaka ; Higuchi, Shigekazu ; Suzuki, Hiroyuki ; Kuriyama, Kenichi ; Enomoto, Minori ; Soshi, Takahiro ; Kitamura, Shingo ; Hida, Akiko ; Mishima, Kazuo. / Increased cerebral blood flow in the right frontal lobe area during sleep precedes self-awakening in humans. In: BMC Neuroscience. 2012 ; Vol. 13, No. 1.
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