Increased heat-escape/cold-seeking behavior following hypertonic saline injection in rats

Kei Nagashima, Sadamu Nakai, Masahiro Konishi, Liu Su, Kazuyuki Kanosue

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12 Citations (Scopus)

Abstract

We examined the effect of hypertonic saline injection on heat-escape/cold-seeking behavior in desalivated rats. Rats were exposed to 40°C heat after normal (154 mM NaCl, control) or hypertonic saline (2,500 mM NaCl) injection (1 ml/100 g body wt). The rats received a 0°C air for 30 s when they entered a specific area in an experimental box. Core temperature (Tc) surpassed 40°C in both conditions when 0°C air was not available. Hypertonic saline injection produced a lower baseline Tc than control [36.9 ± 0.2 and 37.9 ± 0.2°C (means ± SE), P < 0.05] and a greater number of 0±C air rewards during the 2-h heat with lower To at the end (48 ± 1 and 34 ± 2, 37.6 ± 0.1, and 37.3 ± 0.1°C in the control and hypertonic saline injection trial, respectively, P < 0.05, n = 6). However, Tc was similar (37.7 ± 0.2 and 37.6 ± 0.4°C in the control and hypertonic saline injection trial, n = 5) when 0°C air was automatically and intermittently (35 times) given during the heat. Rats augment heat-defense mechanisms in response to osmotic stress by lowering the baseline Tc and increasing heat-escape/cold-seeking behavior.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume280
Issue number4 49-4
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Hot Temperature
Injections
Air
Osmoregulation
Defense Mechanisms
Reward
Temperature

Keywords

  • Desalivation
  • Hyperosmolality
  • Operant behavior

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

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title = "Increased heat-escape/cold-seeking behavior following hypertonic saline injection in rats",
abstract = "We examined the effect of hypertonic saline injection on heat-escape/cold-seeking behavior in desalivated rats. Rats were exposed to 40°C heat after normal (154 mM NaCl, control) or hypertonic saline (2,500 mM NaCl) injection (1 ml/100 g body wt). The rats received a 0°C air for 30 s when they entered a specific area in an experimental box. Core temperature (Tc) surpassed 40°C in both conditions when 0°C air was not available. Hypertonic saline injection produced a lower baseline Tc than control [36.9 ± 0.2 and 37.9 ± 0.2°C (means ± SE), P < 0.05] and a greater number of 0±C air rewards during the 2-h heat with lower To at the end (48 ± 1 and 34 ± 2, 37.6 ± 0.1, and 37.3 ± 0.1°C in the control and hypertonic saline injection trial, respectively, P < 0.05, n = 6). However, Tc was similar (37.7 ± 0.2 and 37.6 ± 0.4°C in the control and hypertonic saline injection trial, n = 5) when 0°C air was automatically and intermittently (35 times) given during the heat. Rats augment heat-defense mechanisms in response to osmotic stress by lowering the baseline Tc and increasing heat-escape/cold-seeking behavior.",
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AU - Nakai, Sadamu

AU - Konishi, Masahiro

AU - Su, Liu

AU - Kanosue, Kazuyuki

PY - 2001

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N2 - We examined the effect of hypertonic saline injection on heat-escape/cold-seeking behavior in desalivated rats. Rats were exposed to 40°C heat after normal (154 mM NaCl, control) or hypertonic saline (2,500 mM NaCl) injection (1 ml/100 g body wt). The rats received a 0°C air for 30 s when they entered a specific area in an experimental box. Core temperature (Tc) surpassed 40°C in both conditions when 0°C air was not available. Hypertonic saline injection produced a lower baseline Tc than control [36.9 ± 0.2 and 37.9 ± 0.2°C (means ± SE), P < 0.05] and a greater number of 0±C air rewards during the 2-h heat with lower To at the end (48 ± 1 and 34 ± 2, 37.6 ± 0.1, and 37.3 ± 0.1°C in the control and hypertonic saline injection trial, respectively, P < 0.05, n = 6). However, Tc was similar (37.7 ± 0.2 and 37.6 ± 0.4°C in the control and hypertonic saline injection trial, n = 5) when 0°C air was automatically and intermittently (35 times) given during the heat. Rats augment heat-defense mechanisms in response to osmotic stress by lowering the baseline Tc and increasing heat-escape/cold-seeking behavior.

AB - We examined the effect of hypertonic saline injection on heat-escape/cold-seeking behavior in desalivated rats. Rats were exposed to 40°C heat after normal (154 mM NaCl, control) or hypertonic saline (2,500 mM NaCl) injection (1 ml/100 g body wt). The rats received a 0°C air for 30 s when they entered a specific area in an experimental box. Core temperature (Tc) surpassed 40°C in both conditions when 0°C air was not available. Hypertonic saline injection produced a lower baseline Tc than control [36.9 ± 0.2 and 37.9 ± 0.2°C (means ± SE), P < 0.05] and a greater number of 0±C air rewards during the 2-h heat with lower To at the end (48 ± 1 and 34 ± 2, 37.6 ± 0.1, and 37.3 ± 0.1°C in the control and hypertonic saline injection trial, respectively, P < 0.05, n = 6). However, Tc was similar (37.7 ± 0.2 and 37.6 ± 0.4°C in the control and hypertonic saline injection trial, n = 5) when 0°C air was automatically and intermittently (35 times) given during the heat. Rats augment heat-defense mechanisms in response to osmotic stress by lowering the baseline Tc and increasing heat-escape/cold-seeking behavior.

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