Increased serum levels of thrombopoietin in patients with thrombotic thrombocytopenic purpura, idiopathic thrombocytopenic purpura, or disseminated intravascular coagulation

K. Hiyoyama, H. Wada, M. Shimura, T. Nakasaki, N. Katayama, M. Nishikawa, H. Shiku, T. Tahara, Takashi Kato

Research output: Contribution to journalArticle

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Abstract

The serum levels of thrombopoietin (TPO) were measured in 16 patients with thrombotic thrombocytopenic purpura (TTP), 12 with hemolytic uremic syndrome (HUS), 10 with aplastic anemia (AA), 10 with disseminated intravascular coagulation (DIC), and 71 with idiopathic thrombocytopenic purpura (ITP). The serum TPO levels were measured with a sensitive sandwich enzyme-linked immunosorbent assay. The serum TPO level in the ITP group (1.68 ± 0.85 fmol/ml) were not significantly increased compared with those of the normal subjects. The TPO levels in the TTP (2.77 ± 1.38 fmol/ml) and HUS groups (5.77 ± 4.41 fmol/ml) were higher than those of the normal subjects. The patients with AA (12.7 ± 8.0 fmol/ml) and those with DIC (13.3 ± 5.7 mol/ml) had significantly higher serum TPO levels than did the normal subjects and ITP patients. The TPO levels were well correlated with the platelet counts in the TIP patients, and were negatively correlated with the platelet counts in the ITP patients. These results suggest that the serum TPO levels in some thrombocytopenic diseases are regulated not only by the platelet count and the megakaryocyte mass, but also by other factors.

Original languageEnglish
Pages (from-to)345-349
Number of pages5
JournalBlood Coagulation and Fibrinolysis
Volume8
Issue number6
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

Thrombopoietin
Thrombotic Thrombocytopenic Purpura
Idiopathic Thrombocytopenic Purpura
Disseminated Intravascular Coagulation
Serum
Platelet Count
Hemolytic-Uremic Syndrome
Aplastic Anemia
Megakaryocytes
Enzyme-Linked Immunosorbent Assay

Keywords

  • Disseminated intravascular coagulation
  • Hemolytic uremic syndrome
  • Idiopathic thrombocytopenic purpura
  • Thrombopoietin
  • Thrombotic thrombocytopenic purpura

ASJC Scopus subject areas

  • Hematology

Cite this

Increased serum levels of thrombopoietin in patients with thrombotic thrombocytopenic purpura, idiopathic thrombocytopenic purpura, or disseminated intravascular coagulation. / Hiyoyama, K.; Wada, H.; Shimura, M.; Nakasaki, T.; Katayama, N.; Nishikawa, M.; Shiku, H.; Tahara, T.; Kato, Takashi.

In: Blood Coagulation and Fibrinolysis, Vol. 8, No. 6, 1997, p. 345-349.

Research output: Contribution to journalArticle

Hiyoyama, K. ; Wada, H. ; Shimura, M. ; Nakasaki, T. ; Katayama, N. ; Nishikawa, M. ; Shiku, H. ; Tahara, T. ; Kato, Takashi. / Increased serum levels of thrombopoietin in patients with thrombotic thrombocytopenic purpura, idiopathic thrombocytopenic purpura, or disseminated intravascular coagulation. In: Blood Coagulation and Fibrinolysis. 1997 ; Vol. 8, No. 6. pp. 345-349.
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