Induction of anovulatory sterility by neonatal treatment with 5β-dihydrotestosterone in female rats

Y. Arai, K. Yamanouchi, S. Mizukami, R. Yanai, K. Shibata, H. Nagasawa

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    21 Citations (Scopus)

    Abstract

    Wistar female rats were injected with testosterone (T) or 5β-dihydrotestosterone (5β-DHT) for the first 5 days of life. Neonatal treatment with 1 mg of T resulted in anovulatory persistent oestrous syndrome in 100% of the animals. In the females injected with 1 mg of 5β-DHT, 74% of the treated rats became sterile at 120 days of age. In addition, 0.5 mg 5β-DHT was also effective in inducing anovulatory persistent oestrus; the incidence of sterility was 10 and 80% at 60 and 120 days of age, respectively. When daily dose of 5β-DHT was reduced to 0.1 mg, however, only 33% of the rats resulted in sterility. These results suggest that the free form of T and non-aromatizable androgen, 5β-DHt, can permanently suppress the development of female type of neuroendocrine regulation. The possible participation of the process other than the central aromatization in androgenization will be discussed.

    Original languageEnglish
    Pages (from-to)439-443
    Number of pages5
    JournalActa Endocrinologica
    Volume96
    Issue number4
    Publication statusPublished - 1981

    ASJC Scopus subject areas

    • Endocrinology

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  • Cite this

    Arai, Y., Yamanouchi, K., Mizukami, S., Yanai, R., Shibata, K., & Nagasawa, H. (1981). Induction of anovulatory sterility by neonatal treatment with 5β-dihydrotestosterone in female rats. Acta Endocrinologica, 96(4), 439-443.