Inferring behavioral-level circuits of Caenorhabditis elegans from the topology of its wiring diagram

Yunkyu Sohn, Jaeseung Jeong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The existence of anatomical basis of functional modularity in the brain has been postulated. Previous studies in the field of theoretical neuroanatomy claimed the segregated nature of cortical areas with their physiological functions by analyzing fiber connection data of mammalian brains. The aim of this study was to investigate, using modularity-based spectral community (cluster) detection algorithm, whether the behavioral-level circuits of Caenorhabditis elegans (C. elegans), which is the only animal that we have a complete wiring diagram of its global nervous system, can be inferred from the topology of its wiring diagram (neuro-synaptic level network) or not. We found that neurons belonging to strong clusters exhibit a hierarchical relationship with the worm's behavioral-level circuits. In addition, we demonstrate the possible existence of strong body-spanning clusters in real neuronal networks.

Original languageEnglish
Title of host publicationProceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE
Pages748-752
Number of pages5
DOIs
Publication statusPublished - 2007 Dec 1
Externally publishedYes
Event7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE - Boston, MA, United States
Duration: 2007 Jan 142007 Jan 17

Publication series

NameProceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE

Conference

Conference7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE
CountryUnited States
CityBoston, MA
Period07/1/1407/1/17

Fingerprint

Caenorhabditis elegans
Electric wiring
Brain
Topology
Neuroanatomy
Networks (circuits)
Neurology
Nervous System
Neurons
Animals
Fibers

Keywords

  • Anatomical cluster
  • Behavioral-level circuits of Caenorhabditis elegans
  • Body-spanning cluster
  • Caenorhabditis elegans nervous system
  • Community detection algorithm
  • Component

ASJC Scopus subject areas

  • Biotechnology
  • Genetics
  • Bioengineering

Cite this

Sohn, Y., & Jeong, J. (2007). Inferring behavioral-level circuits of Caenorhabditis elegans from the topology of its wiring diagram. In Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE (pp. 748-752). [4375644] (Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE). https://doi.org/10.1109/BIBE.2007.4375644

Inferring behavioral-level circuits of Caenorhabditis elegans from the topology of its wiring diagram. / Sohn, Yunkyu; Jeong, Jaeseung.

Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE. 2007. p. 748-752 4375644 (Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sohn, Y & Jeong, J 2007, Inferring behavioral-level circuits of Caenorhabditis elegans from the topology of its wiring diagram. in Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE., 4375644, Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE, pp. 748-752, 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE, Boston, MA, United States, 07/1/14. https://doi.org/10.1109/BIBE.2007.4375644
Sohn Y, Jeong J. Inferring behavioral-level circuits of Caenorhabditis elegans from the topology of its wiring diagram. In Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE. 2007. p. 748-752. 4375644. (Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE). https://doi.org/10.1109/BIBE.2007.4375644
Sohn, Yunkyu ; Jeong, Jaeseung. / Inferring behavioral-level circuits of Caenorhabditis elegans from the topology of its wiring diagram. Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE. 2007. pp. 748-752 (Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE).
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