Influence analysis in quantitative trait loci detection

Xiaoling Dou, Satoshi Kuriki, Akiteru Maeno, Toyoyuki Takada, Toshihiko Shiroishi

Research output: Contribution to journalArticle

Abstract

This paper presents systematic methods for the detection of influential individuals that affect the log odds (LOD) score curve. We derive general formulas of influence functions for profile likelihoods and introduce them into two standard quantitative trait locus detection methods-the interval mapping method and single marker analysis. Besides influence analysis on specific LOD scores, we also develop influence analysis methods on the shape of the LOD score curves. A simulation-based method is proposed to assess the significance of the influence of the individuals. These methods are shown useful in the influence analysis of a real dataset of an experimental population from an F2 mouse cross. By receiver operating characteristic analysis, we confirm that the proposed methods show better performance than existing diagnostics.

Original languageEnglish
Pages (from-to)697-719
Number of pages23
JournalBiometrical Journal
Volume56
Issue number4
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Influence Analysis
Quantitative Trait Loci
Odds
Likelihood Functions
Profile Likelihood
Curve
Influence Function
Operating Characteristics
ROC Curve
Mouse
Diagnostics
Receiver
Interval

Keywords

  • Influence score vector
  • Profile likelihood
  • ROC analysis
  • Shape of LOD score curve
  • Standardized empirical influence function

ASJC Scopus subject areas

  • Statistics and Probability
  • Medicine(all)
  • Statistics, Probability and Uncertainty

Cite this

Dou, X., Kuriki, S., Maeno, A., Takada, T., & Shiroishi, T. (2014). Influence analysis in quantitative trait loci detection. Biometrical Journal, 56(4), 697-719. https://doi.org/10.1002/bimj.201200178

Influence analysis in quantitative trait loci detection. / Dou, Xiaoling; Kuriki, Satoshi; Maeno, Akiteru; Takada, Toyoyuki; Shiroishi, Toshihiko.

In: Biometrical Journal, Vol. 56, No. 4, 2014, p. 697-719.

Research output: Contribution to journalArticle

Dou, X, Kuriki, S, Maeno, A, Takada, T & Shiroishi, T 2014, 'Influence analysis in quantitative trait loci detection', Biometrical Journal, vol. 56, no. 4, pp. 697-719. https://doi.org/10.1002/bimj.201200178
Dou, Xiaoling ; Kuriki, Satoshi ; Maeno, Akiteru ; Takada, Toyoyuki ; Shiroishi, Toshihiko. / Influence analysis in quantitative trait loci detection. In: Biometrical Journal. 2014 ; Vol. 56, No. 4. pp. 697-719.
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