Influence of adiponectin gene polymorphism SNP276 (G/T) on adiponectin in response to exercise training

Hu Huang, Kaoruko Tada Iida, Haruka Murakami, Yoko Saito, Takeshi Otsuki, Motoyuki Iemitsu, Seiji Maeda, Hirohito Sone, Shinya Kuno, Ryuichi Ajisaka

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Adiponectin is an adipocytokine that is involved in insulin sensitivity. The adiponectin gene contains a single nucleotide polymorphism (SNP) at position 276 (G/T). The GG genotype of SNP276 (G/T) is associated with lower plasma adiponectin levels and a higher insulin resistance index. Therefore, we examined the influence of SNP276 (G/T) on the plasma level of adiponectin in response to exercise training. Thirty healthy Japanese (M12/F18; 56 to 79 years old) performed both resistance and endurance training, 5 times a week for 6 months. The work rate per kg of weight at double-product break-point (DPBP) was measured. Blood samples were obtained before and after the experiment. Plasma concentrations of adiponectin, HbA1c, insulin, glucose, total, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) cholesterol, and triglyceride were measured. Genotypes of SNP276 were specified. Student's t-test for paired values and unpaired values was used. After the 6-month training period, the work rate per kg of weight at DPBP and the plasma HDL-cholesterol level were significantly improved (P<0.05), while no change was observed in the total plasma adiponectin level. However, the plasma adiponectin level in those with the GT + TT genotype had significantly increased (P<0.05). Additionally, the degree of the decrease in the HOMA-R level was significantly greater in the subjects with the GT + TT genotype than those with the GG genotype (p<0.05). Our results suggest that subjects with the genotype GT + TT at SNP276 (G/T) have a greater adiponectin-related response to exercise training than those with the GG genotype.

Original languageEnglish
Pages (from-to)879-886
Number of pages8
JournalEndocrine Journal
Volume54
Issue number6
DOIs
Publication statusPublished - 2007
Externally publishedYes

Keywords

  • Adiponectin
  • Exercise training
  • Genotype
  • Insulin sensitivity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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