Influence of caloric restriction and exercise on mitochondrial quality control in skeletal muscle

Satoshi Hattori, Takayuki Akimoto

Research output: Contribution to journalArticle

Abstract

Mitochondria play a central role in energy production but also are the main cellular source of reactive oxygen species (ROS). It is widely believed that aging is related to the accumulation of oxidative molecular damage due to ROS. Aging also induces a decrease in muscle function. Recent studies indicate that caloric restriction and physical exercise suppress the decrease in muscle function though the maintaining quality of mitochondria. This review provides the current understanding of the influence of caloric restriction and exercise on mitochondrial quality control in skeletal muscle.

Original languageEnglish
Pages (from-to)389-396
Number of pages8
JournalJapanese Journal of Physical Fitness and Sports Medicine
Volume64
Issue number4
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Aging
  • Mitochondrial biogenesis
  • Mitophagy
  • Muscle health
  • Oxidative stress

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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