Influence of environmental light-dark cycle and enucleation on activity of suprachiasmatic neurons in slice preparations

Shigenobu Shibata, Yuh Liou Shyh, Showa Ueki, Yutaka Oomura

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

The influence of environmental light-dark cycle (LD) and bilateral enucleation on single neuronal activity in the suprachiasmatic nucleus (SCN) was examined using a hypothalamic slice preparation. Firstly, we reconfirmed previous results that the discharge rate in slices taken from animals kept on normal LD was higher during the light than during the dark period. Secondly, the day time discharge rate in the ventrolateral part of the SCN was decreased by bilateral enucleation and DD housing, while in the dorsomedial part it was unaffected. Thirdly, LL housing suppressed the discharge rates in both parts during the day and night periods. The present results suggest that the dorsomedial part of the SCN is more important in regulation of the circadian rhythm of SCN neuronal activity than the ventrolateral.

Original languageEnglish
Pages (from-to)75-81
Number of pages7
JournalBrain Research
Volume302
Issue number1
DOIs
Publication statusPublished - 1984 Jun 4
Externally publishedYes

Keywords

  • circadian rhythm
  • neuronal activity
  • rat brain slices
  • suprachiasmatic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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