Influences of ventricular assist device pumping on blood coagulation

Y. Taenaka, T. Matsuda, H. Takano, Mitsuo Umezu, T. Akutsu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A left ventricular assist device (VAD) with a smooth surface of segmented polyurethane was implanted in five goats for 10-55 days, and plasma levels of fibrinogen (Fg), prekallikrein (PK), fibrinogen, fibrin degradation products (FDP), antithrombin III (AT III), prothrombin time (PT), partial thromboplastin time (PTT), platelet (PI) count, and platelet aggregation (PIAg) induced by adenosine diphosphate were measured during the experiment. Heparin was administered during surgery and no systemic antithrombotic therapy was given thereafter. Before the third postoperative day (POD), plasma levels of Fg and PK were at their lowest, and increased afterward. Between the second and fifth POD PT and PTT increased to 130-160%, and returned to normal gradually. Plasma FDP appeared on the second POD and reached peak values of 10-40 μg/ml on the sixth POD. Platelet and AT III levels showed no uniform tendency, but the rate of PIAg decreased to levels of 6-77% before the fifth POD and remained low at approximately 80%, influenced by the pumping even after the 25th POD. In summary, VADs the themselves activated coagulation and induced consumption coagulopathy to some degree. However, most of the parameters returned to normal within 2 weeks.

Original languageEnglish
Pages (from-to)396-398
Number of pages3
JournalASAIO Transactions
Volume35
Issue number3
Publication statusPublished - 1989 Jul
Externally publishedYes

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Heart-Assist Devices
Blood Coagulation
Platelets
Coagulation
Prekallikrein
Fibrin Fibrinogen Degradation Products
Blood
Antithrombin III
Partial Thromboplastin Time
Prothrombin Time
Thromboplastin
Prothrombin
Plasmas
Fibrinogen
Left ventricular assist devices
Degradation
Polyurethanes
Disseminated Intravascular Coagulation
Platelet Count
Platelet Aggregation

ASJC Scopus subject areas

  • Biophysics

Cite this

Taenaka, Y., Matsuda, T., Takano, H., Umezu, M., & Akutsu, T. (1989). Influences of ventricular assist device pumping on blood coagulation. ASAIO Transactions, 35(3), 396-398.

Influences of ventricular assist device pumping on blood coagulation. / Taenaka, Y.; Matsuda, T.; Takano, H.; Umezu, Mitsuo; Akutsu, T.

In: ASAIO Transactions, Vol. 35, No. 3, 07.1989, p. 396-398.

Research output: Contribution to journalArticle

Taenaka, Y, Matsuda, T, Takano, H, Umezu, M & Akutsu, T 1989, 'Influences of ventricular assist device pumping on blood coagulation', ASAIO Transactions, vol. 35, no. 3, pp. 396-398.
Taenaka Y, Matsuda T, Takano H, Umezu M, Akutsu T. Influences of ventricular assist device pumping on blood coagulation. ASAIO Transactions. 1989 Jul;35(3):396-398.
Taenaka, Y. ; Matsuda, T. ; Takano, H. ; Umezu, Mitsuo ; Akutsu, T. / Influences of ventricular assist device pumping on blood coagulation. In: ASAIO Transactions. 1989 ; Vol. 35, No. 3. pp. 396-398.
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