Influencing factors in image-based fluid-structure interaction computation of cerebral aneurysms

Ryo Torii*, Marie Oshima, Toshio Kobayashi, Kiyoshi Takagi, Tayfun E. Tezduyar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)


We review and summarize our research activities in fluid-structure interaction (FSI) analysis of cerebral aneurysms using anatomically realistic geometry models based on medical images. Emphasis is placed on influencing factors in computational FSI, and their role and clinical implications are discussed in terms of the wall shear stress (WSS). The key factors are: (1) arterial and aneurysm geometries, (2) wall structure modeling, (3) blood pressure, (4) outflow conditions and (5) inflow conditions. Among these, we find the impact of the arterial and aneurysm geometries to be the most significant. Blood pressure also has a significant impact on the WSS distribution; a hypothetical hypertensive blood pressure condition could help estimate the rupture risk for an aneurysm. We find the other three factors to be minor compared with the arterial and aneurysm geometries and blood pressure, although the level of influence could be unique to the middle cerebral artery aneurysms that we have been focusing on in our studies.

Original languageEnglish
Pages (from-to)324-340
Number of pages17
JournalInternational Journal for Numerical Methods in Fluids
Issue number1-3
Publication statusPublished - 2011 Jan 1
Externally publishedYes


  • Cerebral aneurysm
  • Fluid-structure interaction
  • Image-based modeling
  • Middle cerebral artery
  • Space-time method

ASJC Scopus subject areas

  • Computational Mechanics
  • Mechanics of Materials
  • Mechanical Engineering
  • Computer Science Applications
  • Applied Mathematics


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